补肾育子汤加减联合克罗米芬治疗无排卵型不孕症临床研究  

Effect of Bushen Yuzi Decoction Combined with Clomiphene in Treatment of Anovulatory Infertility

作　　者：曹利萍 CAO Liping(Yulin Hospital of Traditional Chinese Medicine, Yulin, Shaanxi 719000, China)

机构地区：[1]陕西省榆林市中医医院,陕西榆林719000

出　　处：《湖南中医药大学学报》2018年第5期566-569,共4页Journal of Hunan University of Chinese Medicine

基　　金：陕西省中医药管理局科研课题(LCMS020)

摘　　要：目的观察补肾育子汤加减联合克罗米芬治疗无排卵型不孕症临床疗效。方法将480例无排卵型不孕症患者随机分为治疗组和对照组各240例,治疗组口服中药补肾育子汤加减和西药克罗米芬,对照组仅给予克罗米芬,对照组和治疗组均观察3个月。结果治疗组排卵率82.5%、妊娠率60.8%、黄素化未破裂卵泡综合征(LUFS)发生率14.2%,对照组排卵率69.6%、妊娠率38.7%、LUFS发生率28.7%,两组比较均差异有统计学意义(P<0.05);两组治疗后子宫内膜厚度、最大卵泡直径比较,差异有统计学意义(P<0.01)。结论补肾育子汤加减联合克罗米芬治疗无排卵型不孕,能促进卵泡发育和排卵,降低LUFS发生率,增加子宫内膜容受性,提高临床妊娠率,疗效显著。Objective To observe the effect of Bushen Yuzi decoction combined with clomiphene in treating anovulatory infertility. Methods The 480 patients with anovulatory infertility were randomly divided into the treatment group and control group, with 240 cases in each group. The treatment group was administrated with Bushen Yuzi decoction and clomiphene, the control group was treated with clomiphene, the two groups were treated for 3 months. Results The ovulation rate in the treatment group was 82.5%, the pregnancy rate was 60.8%, and the incidence rate of luteinized unruptured follicle syndrome（LUFS） was 14.2%. In the control group, the ovulation rate was 69.6%, pregnancy rate was 38.7%, and the incidence rate of LUFS was 28.7%. The differences between the two groups were statistically significant（P〈0.05）. After treatment, the thickness of endometrium and the maximum follicle diameter were statistically significant（P〈0.01）. Conclusion Bushen Yuzi decoction combined with clomiphene shows good effect in treating anovulatory infertility, which can promote follicular development and ovulation, reduce the incidence of LUFS, increase endometrial receptivity, improve the clinical pregnancy rate.

关 键 词：无排卵型不孕症 补肾育子汤加减 克罗米芬 临床观察 

分 类 号：R271.14[医药卫生—中医妇科学] R711.6[医药卫生—中医学]