双黄花片对急性上呼吸道感染患者炎症因子及免疫功能的影响  

Effect of Shuanghuanghua Tablet on Inflammatory Factors and Immune Function in Patients with Acute Upper Respiratory Infection

作　　者：王华[1] 孟盼[2] 陈鸣凤 张素英[2] WANG Hua;MENG Pan;CHEN Mingfeng;ZHANG Suying(The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;4. The Eighth Hospital ofChangsha, Changsha, Hunan 410100, Chin)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学,湖南长沙410208 [3]长沙市八医院,湖南长沙410100

出　　处：《湖南中医药大学学报》2018年第5期570-573,共4页Journal of Hunan University of Chinese Medicine

基　　金：湖南省高校创新平台开放基金项目(13K075)

摘　　要：目的探讨双黄花片对急性上呼吸道感染患者炎症因子和免疫功能的影响。方法将72例受试者按1∶1的比例,随机分为双黄花片治疗组和感冒清片对照组,疗程5 d;观察急性上呼吸道感染疾病的临床疗效,采用双抗体夹心ABC-ELISA法测定血清炎症因子IL-2、IL-6、IL-8、TNF-α含量,流式细胞仪(FACS Calibur)检测外周血T细胞亚群CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平。结果经治疗后,治疗组疾病综合疗效明显高于对照组(P<0.01)。治疗组患者血清炎症因子IL-2、IL-6、IL-8、TNF-α水平明显低于对照组,差异有统计学意义(P<0.05)。治疗组患者的T细胞亚群CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平明显高于对照组,差异有统计学意义(P<0.05)。结论双黄花片治疗急性上呼吸道感染有较好的疗效,可降低炎症因子水平,提高机体免疫能力。Objective To explore the effect of Shuanghuanghua tablet on inflammatory factors and immune function in patients with acute upper respiratory infection. Methods A randomized method was used to divide 72 subjects into the treatment group（Shuanghuanghua tablet） and the control group（Ganmaoqing tablet）, according to the proportion of 1：1, with a course of 5 days. The clinical efficacy of acute upper respiratory tract infection was observed. The serum inflammatory factors interleukin 2（IL-2）, interleukin 6（IL-6）, interleukin 8（IL-8） and tumor necrosis factor alpha（TNF-α） were determined by double-antibody sandwich ABC-ELISA. The level of T cell subsets of peripheral blood CD3^＋, CD4^＋, CD8^＋ and CD4^＋/CD8^＋ was detected by Flow cytometry（FACS Calibur）. Results After treatment, the curative effect of the treatment group was significantly higher than the control group（P〈0.01）. The levels of serum inflammatory factors IL-2, IL-6, IL-8 and TNF-α in the treatment group were significantly lower than the control group, the difference was statistically significant（P〈0.05）. The T-cell subgroup CD3^＋, CD4^＋, CD8^＋ and CD4^＋/CD8^＋ in the treatment group were significantly higher than the control group,the difference was statistically significant（P〈0.05）. Conclusion Shuanghuanghua tablet has a good therapeutic effect on acute upper respiratory infection, which can reduce the level of inflammatory factors and improve the immune ability of the body.

关 键 词：急性上呼吸道感染 风热证 双黄花片 炎症因子 免疫功能 

分 类 号：R289.5[医药卫生—方剂学] R254.1[医药卫生—中药学]