慢性乙型肝炎患者肝组织病理分级与其他临床指标的关系研究  

Relationship between liver pathological grade and other clinical indexes in patients with chronic hepatitis B

作　　者：胡春玲[1] 王佳[1] 顾心雨 武淑环[1] 余祖江[1] 李志勤[1] Hu Chunling;Wang Jia;Gu Xinyu;Wu Shuhuan;Yu Zujiang;Li Zhiqin(Department of Infection, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Chin)

机构地区：[1]郑州大学第一附属医院感染科,河南郑州450052

出　　处：《河南医学研究》2018年第8期1364-1366,共3页Henan Medical Research

摘　　要：目的研究慢性乙型肝炎(CHB)患者肝组织病理分级与其他临床指标的关系。方法回顾性分析106例CHB患者,根据年龄≥40岁或年龄<40岁、ALT≥80 IU/L或ALT<80 IU/L、HBV-DNA≥10~7拷贝/ml或HBV-DNA<10~7拷贝/ml、HBeAg阳性或阴性各分两组,分别对比分析两组间的炎症分级和纤维化分期情况,并进行统计学分析。结果年龄大小与不同ALT水平两方面,两组间肝组织纤维化分期比较,差异有统计学意义(均P<0.05),炎症分级比较,差异无统计学意义(P>0.05);在不同的HBV-DNA水平与HBeAg阳性与否两方面,两组间肝组织纤维化分期与炎症分级比较,差异无统计学意义(P>0.05)。结论在CHB患者中,年龄与血清ALT水平与肝组织病理分期具有一定的相关性。Objective To study the relationship between pathological staging and other clinical parameters in patients with chronic hepatitis B（CHB）. Methods Retrospective analysis of 106 patients with CHB according to age≥40 or age 40 years,ALT≥80 IU/L or ALT〈80 IU/L,HBV-DNA≥10^7 copies/ml or HBV-DNA 〈10^7 copies/ml,HBeAg positive or negative in two groups,were compared between the two groups of inflammation grading and fibrosis staging,and statistical analysis.Results There were significant differences in age and size of ALT levels between the two groups in liver fibrosis stages（all P〈0. 05）. There was no significant difference in inflammatory grades（P〉0. 05）. Whether the level of HBV-DNA and HBeAg was positive or not,there was no significant difference in liver fibrosis staging and inflammation grading between the two groups（P〉0. 05）. Conclusion The age and serum ALT levels in CHB patients have a certain correlation with the pathological staging of liver tissue.

关 键 词：慢性乙型肝炎 病理 炎症 纤维化 年龄 丙氨酸氨基转移酶 乙肝病毒脱氧核糖核酸 

分 类 号：R512.62[医药卫生—内科学]