衣原体致病机制研究进展  

Progress of research on pathogenic mechanisms in Chlamydia

作　　者：陈浩[1] 周洲[1] CHEN Hao;ZHOU Zhou(Institution of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, China)

机构地区：[1]南华大学病原微生物学研究所,衡阳421001

出　　处：《中国免疫学杂志》2018年第5期780-785,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(No.31570179;30901352);湖南省分子靶标新药研究协同创新中心资助项目(No.2015-351);特殊病原体防控湖南省重点实验室资助项目(No.2014-5号);湖南省重点学科资助项目(No.2011-76)

摘　　要：衣原体是一类严格细胞内寄生,具有独特发育周期的原核细胞型微生物,它感染人体可以引起多种疾病,包括沙眼、肺炎和泌尿生殖道感染等。由于衣原体特殊生长条件及其研究手段的局限,阻碍了衣原体致病机制的深入研究。本文从衣原体的生物学特性、黏附与穿入、调控宿主信号通路及对其产生的病理损伤、与宿主细胞凋亡相关关系、免疫逃逸几个方面对衣原体的致病机制进行综述。Chlamydia is a strict intracellular parasite with unique developmental cycle. It can cause various diseases,including trachoma,pneumonia and urogenital tract infections. Due to the special conditions of Chlamydia growth and the limitations of its research methods,the pathogenesis of Chlamydia has been hindered. The pathogenesis of Chlamydia is reviewed from the following aspects： biological characteristics,adhesion and penetration,regulation of host signaling pathways,pathological damage,host cell apoptosis and immune escape.

关 键 词：衣原体 致病机制 黏附和穿入 细胞凋亡 免疫逃逸 

分 类 号：R374[医药卫生—病原生物学]