支气管肺泡灌洗阿米卡星治疗支气管扩张感染的临床疗效及对炎症因子的影响  

Clinical efficacy of bronchoscopic injection of Amikacin in the treatment of bronchiectasis and its influence on inflammatory factors

作　　者：张学平[1] 马小芬 赵娜[1] 王孟 翟云青[1] ZHANG Xueping, MA Xiaofen ,ZHAO Na, WANG Meng ,ZHAI Yunqing(Department of Respiratory Medicine, Binzhou Central Hospital, Binzhou 251700, P. R. Chin)

机构地区：[1]滨州市中心医院呼吸内科,滨州251700

出　　处：《滨州医学院学报》2018年第2期116-118,共3页Journal of Binzhou Medical University

摘　　要：目的研究支气管肺泡灌洗阿米卡星治疗支气管扩张感染的临床疗效及对炎症因子的影响,为临床治疗提供参考依据。方法选取支气管扩张症合并感染患者72例,随机分成对照组和观察组各36例,两组均予以常规内科治疗,对照组给予常规支气管镜检查以及生理盐水灌洗,观察组在常规支气管镜检查基础上病变肺段注入阿米卡星,观察两组临床治疗效果及对炎症因子的影响。结果观察组总有效率为97.22%,明显高于对照组83.33%(P<0.05);观察组在发热,咳嗽,咳痰,呼吸困难消失时间,抗生素用药时间及住院时间均明显低于对照组(P<0.05);两组患者治疗后CRP,PCT和IL-6水平均明显下降,其中观察组水平明显低于对照组(P<0.05)。结论支气管肺泡灌洗阿米卡星治疗支气管扩张感染能有效抑制炎症因子水平,临床疗效确切,值得临床推广应用。Objective To analyze the therapeutic effect of bronchoscopic injection of Amikacin on bronchiectasis and its influence on inflammatory factors.Methods A total of 72 patients with bronchiectasis were selected,they were randomly divided into control group and observation group,two groups were given routine medical treatment.The control group was intravenous injected with Amikacin and bronchoalveolar lavage with physiological saline,and the observation group was given Amikacin by bronchoscope,the clinical effect was synthetically analyzed.Results The total effective rate of the observation group（97.22% ）was higher than that of the control group（83.33% ）;the symptoms disappeared and antibiotic application time was shorter than that in the control group,and the difference was statistically significant（P〈0.05）;CRP,MMP-9 and IL-6 inflammatory factors after treatment were significantly lower in the observation group than that in the control group,P〈0.05.Study showed that 25 cases were markedly effective,10 cases effective,1 cases ineffective,the total effective rate was 97.22% ,16 cases of control group were markedly effective,14 cases effective,6 cases ineffective,the total effective rate was 83.33% ,there was significant difference between groups（χ-2=3.9560,P〈0.05）.Conclusion Bronchoscopic injection of Amikacin can significantly improve the bronchiectasis symptoms and inflammatory factors and improve the curative effect.

关 键 词：支气管扩张症 支气管镜 阿米卡星 炎症因子 

分 类 号：R562.22[医药卫生—呼吸系统]