口服补液盐Ⅲ治疗杯状病毒腹泻患儿临床回顾性研究  

A retrospective cohort study of ORS Ⅲ on treatment of calicivirus diarrhea in hospitalized children

作　　者：向梅 熊励晶 谢晓丽 廖雪春[2] 马小珍[2] 欧小琴 杨静 蒋茂林 XIANG Mei1,XIONG Lijing1,XIE Xiaoli1,LIAO Xuechun2,MA Xiaozhen2,OU Xiaoqin1,YANG Jing1,JIANG Maolin1(1. Department of Pediatric Gastroenterology, Chengdu Women＇s and Children＇s Central Hospital, Chengdu 610091, China ; 2. Institute of Microbiology ,Sichuan Center for Disease Control and Prevention, Chengdu 610041, Chin)

机构地区：[1]成都市妇女儿童中心医院儿童消化科,四川成都610091 [2]四川省疾病预防控制中心微生物检疫所,四川成都610041

出　　处：《西部医学》2018年第5期668-671,共4页Medical Journal of West China

基　　金：国家"十二五"科技重大专项(2012ZX10004-212);成都市卫计委课题(2016136)

摘　　要：目的了解成都地区2012~2014年住院腹泻患儿人杯状病毒感染情况,探讨口服补液盐Ⅲ(ORSⅢ)治疗杯状病毒腹泻患儿的临床安全性与有效性。方法采用RT-PCR方法对腹泻患儿粪便进行人杯状病毒检测。并将杯状病毒感染患儿分成两组:A组67例患儿使用口服补液盐Ⅲ;B组74例患儿不使用口服补液盐Ⅲ,其余治疗相同,比较两组临床疗效与安全性。结果 2012~2014年病毒性腹泻住院患儿共1064例,其中杯状病毒感染267例(25.1%),三年分别为28.4%(93/328)、21.6%(100/463)、27.1%(74/273)。在267例中141例人杯状病毒感染患儿纳入研究,其中A组67例患儿脱水纠正时间较B组明显缩短、入院后24小时静脉输液量较B组明显减少(P<0.05),且血钠浓度较B组患儿高,但仍在正常范围内。两组患儿血钾浓度及住院时间差异无统计学意义。结论杯状病毒感染是成都地区引起婴幼儿腹泻的常见病原体之一,口服补液盐Ⅲ治疗杯状病毒腹泻住院患儿可有效缩短腹泻病程、脱水纠正时间以及减少入院后24小时静脉输液量。Objective To identify the epidemiology of human calicivirus-related diarrhea of children under 5 years old in Chengdu and discuss clinical safety and efficacy of ORS Ⅲ on calicivirus diarrhea in hospitalized children.Methods RT-PCR was used to detect the virus from stool specimens.The positive cases of calicivirus-infected children were divided into group A treated with ORS Ⅲ and group B treated without ORS Ⅲ.The clinical safety and efficacy were observed.Results 1064 specimens were collected from children suffered with diarrhea.The annual detection rate 2012,2013 and2014 were 28.4%,21.6%and 27.1%,respectively.There were no significant differences in the number of days of diarrhea and the number of diarrhea before hospitalized.There was significant difference between the two groups in the time of diarrhea remission,the time of dehydration correction,the amount of intravenous infusion and the concentration of sodium and sodium in the 24 hours after admission.After the use of ORS Ⅲ,the time of dehydration correction was shortened and the amount of intravenous infusion was significantly reduced after 24 hours.Concentration of serum sodium was higher than that of unused children,but still within normal range.There was no significant difference in serum potassium concentration and hospitalization time between the two groups.Conclusion Human calicivirus has become one of the leading pathogens that contributed to diarrhea of children under age 5 in Chengdu.ORS Ⅲ treatment of calicivirus diarrhea hospitalized children can help shorten the course of diarrhea,dehydration correction time and reduce the amount of intravenous infusion 24 hours after admission.

关 键 词：口服补液盐Ⅲ 人杯状病毒 回顾性队列研究 

分 类 号：R723.11[医药卫生—儿科]