维生素K治疗儿童废用性骨质疏松的疗效观察  

Efficacy of vitamin K for the treatment of disuse osteoporosis in children

作　　者：胡雪松[1] 覃佳强[2] 郭彬 刘明怀 彭方毅 石立鹏[1] 许一帆 HU Xuesong1,QIN Jiaqiang2,GUO Bin3,LIU Minghuai2,PENG Fangyi2,SHI Lipeng1,XU Yifan1(1. Hunan University of Chinese Medicine, Changsha 410000, China ; 2. Chinese Medicine Hospital of Dianjiang , Dianjiang 408300, Chongqing, China ; 3.Children＇s Hospital Affiliated to Medical University of Chongqing ,Chongqing 400010, Chin)

机构地区：[1]湖南中医药大学,湖南长沙410000 [2]重庆医科大学附属儿童医院,重庆400010 [3]重庆市垫江县中医院,重庆垫江408300

出　　处：《西部医学》2018年第5期704-706,共3页Medical Journal of West China

基　　金：重庆市卫生计生委医学科研项目(2015ZBXM015);垫江县科技计划项目(djkjxm2016jsyfysfyy031)

摘　　要：目的观察维生素K对废用性骨质疏松儿童患者的骨密度(BMD)、血钙、血磷、骨碱性磷酸酶(BALP)、骨钙素(BGP)的影响。方法将符合纳入标准的废用性骨质疏松儿童患者60例,随机分为对照组和治疗组各30例,对照组每日口服钙尔奇D片,治疗组在此基础上口服维生素K片。两组连续治疗3个月。观察治疗前后患儿的BMD、血钙、血磷、BALP、BGP的变化情况。结果治疗后两组BMD、BGP均明显升高(P<0.05),且治疗组的BMD、BGP上升幅度均明显高于对照组,具有显著差异(P<0.05);治疗后两组BALP均明显下降(P<0.05),且治疗组BALP下降幅度明显大于对照组,具有显著差异(P<0.05),两组血钙、血磷治疗前后无明显变化(P>0.05)。结论维生素K联合钙尔奇D治疗儿童废用性骨质疏松的疗效明显优于单用钙尔奇D。Objective To study the impacts of vitamin K on bone mineral density（BMD）,serum calcium,phosphate,bone alkaline phosphate（BALP）and Bone Glaproteinin（BGP）in disuse osteoporosis children.Methods Sixty disuse osteoporosis children were randomly divided into treatment group and control group.Control group children only took caltrate D orally daily.On this basis,observation group children took vitamin K orally daily.All the children were treated for 3 months.After treatment,we observed changes of BMD,serum calcium,phosphate,BALP and BGP.Results BMD and BGP were significantly increased（P〈0.05）,and the higher BMD and BGP existed in treatment group（P〈0.05）,BALP were decreased obviously（P〈0.05）,and the lower BALP existed in treatment group（P〈0.05）.The result of serum calcium,phosphorus showed no significant change（P〉0.05）.Conclusion Vitamin K combine with caltrate D has the better therapy effects than only caltrate D in the disuse osteoporosis children.

关 键 词：维生素K 儿童 废用性 骨质疏松 临床观察 

分 类 号：R681[医药卫生—骨科学]