慢性肾衰竭维持性血液透析合并不宁腿综合征的中医证候研究  

Investigation of Traditional Chinese Medicine Syndromes of Chronic Renal Failure Maintenance Hemodialysis Patients Complicated with Restless Leg Syndrome

作　　者：林燕娜 冯志瑀[2] 黎志彬[1] 王超[2] 宋慧锋[2] 吴兴波[2] LIN Yan-Na;FENG Zhi-Yu;SONG Hui-Feng;LI Zhi-Bin;WANG Chao;WU Xing-Bo(Guangzhou University of Chinese Medicine, Guangzhou 510405 Guangdong, China;Nephrology Dept., the First Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou 510405 Guangdong, China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院肾病科,广东广州510405

出　　处：《广州中医药大学学报》2018年第3期383-387,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研课题(编号:20152120)

摘　　要：【目的】探讨慢性肾衰竭维持性血液透析(MHD)患者合并不宁腿综合征(RLS)中医证候的分布规律及相关性。【方法】纳入MHD患者304例,采集患者中医四诊信息进行辨证分型得出其中医证候规律,比较各证候RLS的患病率;同时,比较不同转铁蛋白饱和度(TS)下RLS及其证候分布情况。【结果】(1)MHD患者各中医证候RLS患病率比较,差异有统计学意义(P<0.05);本虚证中的气阴两虚证、肝肾阴虚证RLS患病率较高,分别为33.3%、23.5%;标实证中血瘀证的患病率较高,为21.6%。(2)TS<20%的透析患者合并RLS的比例较TS≥20%的高,差异有统计学意义(P<0.05);气阴两虚证、肝肾阴虚证的透析患者TS<20%的百分比较其他证候高,差异有统计学意义(P<0.05)。【结论】气阴两虚证、肝肾阴虚证是血液透析合并RLS的高危证候,临床上需注意气阴两虚证、肝肾阴虚证透析患者的TS水平。Objective To explore the distribution of traditional Chinese medicine（TCM）syndromes in chronic renalfailure（CRF）maintenance hemodialysis（MHD）patients complicated with restless leg syndrome（RLS）. Methods The clinical data of 304 cases of CRF-MHD patients complicated with RLS were collected by four diagnosticmethods for the differentiation of TCM syndromes. The morbidity rate of RLS in various syndrome types of CRF-MHD patients was analyzed,and the distribution of RLS and syndrome types in CRF-MHD patients with varioustransferrin saturation（TS）was also investigated. Results（1）The differences of the morbidity rate of RLS in varioussyndrome types of CRF-MHD patients were significant（P〈0.05）. In the healthy-Qi deficiency syndromes,Qi-yin deficiency syndrome and liver-kidney Yin deficiency syndrome had the higher morbidity rate of RLS,being33.3% and 23.5%, respectively. In the pathogen-excessive syndromes, blood stasis syndrome had the highermorbidity rate of RLS,being 21.6%.（2）The proportion of MHD patients with TS20% complicated with RLS washigher than that of MHD patients with TS ≥ 20%,the difference being significant（P〈0.05）. The proportion ofTS20% patients with Qi-yin deficiency syndrome and liver-kidney Yin deficiency syndrome was higher than thatof TS20% patients with other syndrome types,the difference being significant（P〈0.05）. Conclusion Qi-yin deficiency syndrome and liver-kidney Yin deficiency syndrome are the risky syndromes for MHD patientscomplicated with RLS,and more attention should be paid to the TS level of these patients.

关 键 词：慢性肾衰竭 维持性血液透析 不宁腿综合征 气阴两虚证 肝肾阴虚证 血瘀证 

分 类 号：R692.5[医药卫生—泌尿科学] R747.9[医药卫生—外科学]