通癃启闭汤对良性前列腺增生症患者血清性激素水平及IPSS和IIEF-5评分的影响  

Effect of Tonglong Qibi Decoction on Serum Sexual Hormone Level,IPSS and IIEF-5 Scores in Patients with Benign Prostatic Hyperplasia

作　　者：游旭军 李其信[1] 傅伟[1] 远庚彦[1] 丁劲 YOU Xu-Jun;LI Qi-Xin;FU Wei;YUAN Geng-Yan;DING Jing(Andrology Dept. of Shenzhen Bao＇an Hospital of Traditional Chinese Medicine, Shenzhen 518101 Guangdong, China)

机构地区：[1]广东省深圳市宝安区中医院男科,广东深圳518101

出　　处：《广州中医药大学学报》2018年第3期402-407,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(编号:2016A020215198);深圳市卫生计生系统科研项目(编号:201501049);深圳市宝安区科技创新局科研课题(编号:2015068)

摘　　要：【目的】观察通癃启闭汤对良性前列腺增生症(BPH)患者血清性激素水平及国际前列腺症状评分(IPSS)和国际勃起功能评分(IIEF-5)的影响。【方法】将65例BPH患者随机分为中药组33例和对照组32例。中药组给予口服通癃启闭汤治疗,对照组给予口服非那雄胺片治疗。2组均以30 d为1个疗程,共治疗2个疗程。观察2组患者治疗前后中医证候积分、血清睾酮(T)、雌二醇(E2)水平、IPSS和IIEF-5评分的变化情况,并评价2组临床疗效及安全性。【结果】(1)中药组脱落2例,对照组脱落1例,无剔除及终止病例。(2)经2个疗程治疗后,中药组的总有效率为87.1%,对照组为67.7%,中药组的中医证候疗效优于对照组(P<0.05)。(3)治疗后,2组患者的中医证候积分均较治疗前明显降低(P<0.05),且中药组的降低作用明显优于对照组(P<0.05)。(4)治疗后,2组患者血清T水平均无显著性变化(P>0.05),而中药组患者血清E2水平较治疗前明显下降(P<0.05),中药组对血清E2水平的改善作用明显优于对照组(P<0.05)。(5)治疗后,2组患者IPSS评分均较治疗前明显下降(P<0.05),中药组患者IIEF-5评分较治疗前提高(P<0.05),对照组患者IIEF-5评分较治疗前下降(P<0.05),中药组在改善IIEF-5评分方面的作用优于对照组(P<0.05)。(6)试验过程中,2组患者均未见明显不良反应和肝肾功能损害。【结论】通癃启闭汤能改善肾虚血瘀型BPH患者的中医临床证候,且在减少患者勃起功能障碍的副作用方面具有明显优势,其作用机理可能与抑制血清雌激素水平有关。Objective To observe the effect of Tonglong Qibi Decoction on serum sexual hormone level,International Prostate Symptom Scores（IPSS）and International Index of Erectile Function（IIEF-5）scores inpatients with benign prostatic hyperplasia. Methods Sixty-five cases of benign prostatic hyperplasia were randomlydivided into Chinese medicine group（n = 33）and control group（n = 32）. The Chinese medicine group was givenoral use of Tonglong Qibi decoction,and the control group was treated with Finasterride tablets orally. Thirty daysconstituted one treatment course,and the two groups were treated for 2 courses. The changes of traditional Chinesemedicine（TCM）symptom scores,serum testosterone（T）and estradiol（E2）levels,and IPSS and IIEF-5 scoresin two groups were observed before and after treatment. After treatment,the clinical efficacy and safety were alsoevaluated. Results（1）Two cases from the Chinese medicine group and one case from the control group weredropped out,but there was no excluded case or cases of discontinued treatment.（2）After treatment for 2 courses,the total effective rate of the Chinese medicine group was 87.1%,and that of the control group was 67.7%,thedifference being significant（P〈0.05）.（3）After treatment,the TCM symptom scores of the two groups were lowerthan those before treatment（P〈0.05）,and the decrease in the Chinese medicine group was superior to that in the control group（P〈0.05）.（4）There was no significant difference in serum T level between the two groups before andafter treatment（P〈0.05）. Serum E2 level was decreased in Chinese medicine group（P〈0.05 compared with thatbefore treatment）,and the decrease was superior to that in the control group（P〈0.05）.（5）IPSS were obviouslydecreased in the two groups（P〈0.05）,and IIEF-5 scores were increased in the Chinese medicine group but weredecreased in the control group after treatment（P〈0.05）. Chinese medicine group had better effect on improvingIIEF-5 scores than

关 键 词：通癃启闭汤 良性前列腺增生症 血清性激素 IPSS评分 IIEF-5评分 

分 类 号：R277.5[医药卫生—中医学] R697.32