超滤——反渗透结合谱效分析法纯化浓缩糖肾康颗粒提取液的工艺评价与验证  

Process Evaluation and Verification for Purification and Concentration of Tangshenkang Granules Extracts by Ultrafiltration-Reverse Osmosis Combined with Chromatography

作　　者：邝洁容[1] 陈伯丛[1] KUANG Jie-Rong;CHEN Bo-Cong(Foshan Hospital of Traditional Chinese Medicine, Foshan 528000 Guangdong, Chin)

机构地区：[1]广东省佛山市中医院,广东佛山528000

出　　处：《广州中医药大学学报》2018年第3期501-506,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(编号:2011A080504005)

摘　　要：【目的】结合谱效分析优化超滤—反渗透纯化浓缩糖肾康颗粒提取液的工艺条件。【方法】以成分富集、效应和安全性为指标,考察超滤—反渗透纯化浓缩技术的效果。【结果】超滤—反渗透可以有效富集效应成分,降低含固量,保证药效,提高效应。【结论】采用超滤—反渗透技术纯化浓缩糖肾康颗粒提取液是可行的,并为该技术用于中药提取液的精制和浓缩提供可靠的实验依据。Objective To optimize the process conditions of ultrafiltration-reverse osmosis combined withchromatography for purification and concentration of Tangshenkang Granules extracts. Methods With theenrichment of ingredients,pharmacodynamic effects and toxicological action as observation indexes,the efficacyof ultrafiltration-reverse osmosis purification and concentration technique was investigated. Results Ultrafiltration-reverse osmosis is effective for enriching the effective components, reducing the solid content, ensuring thepharmacodynamic effects, and improving the efficacy. Conclusion It is feasible to purify and concentrate Tangshenkang Granules extracts by ultrafiltration-reverse osmosis technique. The results will provide a reliableexperimental basis for the purification and concentration of Chinese medicine extracts.

关 键 词：糖肾康颗粒 超滤—反渗透 成分富集 安全性 

分 类 号：R284.2[医药卫生—中药学]