聚合物胶束载药体系研究进展  

Research Progress in Polymeric Micelle Drug-Loading System

作　　者：李媛媛[1] 孙祥科 李伟[1] 陈左生[2] 宿烽[1] 宋益民[1] LI Yuan-yuan;SUN Xiang-ke;LI Wei;CHEN Zuo-sheng;SU Feng;SONG Yi-min(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;College of Knvirornnental Science and Engineering , Peking University , Beijing 100871 , China)

机构地区：[1]青岛科技大学化工学院,山东青岛266042 [2]北京大学环境科学与工程学院,北京100871

出　　处：《化学与生物工程》2018年第5期1-4,10,共5页Chemistry & Bioengineering

基　　金：国家自然科学基金面上项目(81570287);山东省科技攻关计划项目(2015GGX102017);青岛市成果转换计划科技惠民专项(16-6-2-9-nsh;16-6-2-17-nsh)

摘　　要：两亲性嵌段共聚物能够在水溶液中通过自组装形成聚合物胶束,其疏水嵌段构成胶束内核,可以有效包载疏水性药物;而亲水嵌段构成胶束外壳,有利于胶束的稳定和体内长循环。聚合物胶束作为药物载体得到了广泛研究,有些已经进入了临床试验和应用阶段。概述了聚合物胶束的特点,介绍了聚合物胶束的组成、载药胶束的制备方法以及聚合物胶束作为药物传递系统的一些实例,并对聚合物胶束载药体系的研究方向进行了展望。Amphiphilic block copolymers can form polymeric micelles through self-assembly in aqueous solution,in which the hydrophobic blocks constitute the core of micelle which allows to encapsulate hydrophobic drugs,while the hydrophilic blocks constitute the shell of micelle which benefits the stability of micelle and long circulation in the bloodstream. Polymeric micelles have been widely studied as drug carriers,and some of them have entered the stages of clinical trials and application. We summarize the characteristics of polymeric micelles,and introduce the composition of polymeric micelles,the preparation methods of drug-loading micelles,and examples of polymeric micelles as drug delivery systems.Finally,we prospect the research direction of polymeric micelle drug-loading system in the future.

关 键 词：两亲性嵌段共聚物 自组装 聚合物胶束 疏水性药物 药物传递系统 

分 类 号：Q648.1[生物学—生物物理学] R942[医药卫生—药剂学]