痤疮与皮肤屏障  

The acne and skin barrier

作　　者：宋凡君 张邵婕 肖斌[1] 杨桂兰[1] SONG Fan-jun, ZHANG Shao-jie, XIAO Bin, et al(Department of Dermatology, Gansu Lanzhou Military Region General Hospital, Lanzhou 730050, Chin)

机构地区：[1]兰州军区兰州总医院皮肤科,兰州730050

出　　处：《实用皮肤病学杂志》2018年第2期97-100,共4页Journal of Practical Dermatology

基　　金：甘肃省自然科学基金项目(1506RJZA308)

摘　　要：痤疮是一种好发于青少年常见的毛囊皮脂腺的慢性炎症性皮肤病,可导致炎症后色素沉着和永久性瘢痕。痤疮的发生发展与皮肤屏障功能有着密切的关系,痤疮发病机制中皮脂分泌增多、毛囊上皮角化过度、致病性痤疮丙酸杆菌定植、炎症反应等因素均会引起皮肤屏障功能损伤,而皮肤屏障功能的损伤加剧了痤疮病情。因此,在治疗痤疮的同时,修复皮肤屏障功能是痤疮防治的重要环节。Acne is a chronic inflammatory skin disease of hair follicles and sebaceous glands, that commonly occurs in adolescents, and may result in post-inflammatory pigmentation and permanent scar. There is a close relationship between the occurrence and development of acne and skin barrier function. In the pathogenesis of acne, sebum secretion, hair follicle hyperkeratosis, Propionibacterium pathogenic colonization, inflammation and other factors will cause the damage of barrier function of skin, and skin barrier function damage will aggravate acne conversely. Therefore, repair of skin barrier function is an important part of acne prevention and treatment.

关 键 词：痤疮 皮肤屏障 发病机制 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]