糖尿病患者颈动脉弹性功能与血清MMP-9水平的相关性研究  

Correlation of carotid artery elasticity and serum MMP-9 level in diabetic patients

作　　者：张怡然 孙传青 车国英[1] 苏雁欣[1] ZHANG Yiran;SUN Chuanqing;CHE Guoying;SU Yanxin(Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)

机构地区：[1]哈尔滨医科大学附属第二医院超声医学科

出　　处：《临床超声医学杂志》2018年第5期318-321,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨糖尿病患者颈动脉弹性指标与血清基质金属蛋白酶-9(MMP-9)水平的相关性。方法选取糖尿病颈动脉内膜未见明显改变患者31例(内膜正常组)、糖尿病颈动脉内膜增厚及斑块形成患者40例(内膜改变组)及健康志愿者30例(正常对照组),应用酶联免疫吸附试验检测各组血清MMP-9水平,血管回声跟踪(ET)技术检测并比较各组颈动脉僵硬度(β)、压力弹性应变系数(Eρ)、顺应性(AC)、增大指数(AI)及脉搏波传导速度(PWVβ),分析糖尿病患者血清MMP-9水平与颈动脉弹性指标的相关性。结果与正常对照组比较,内膜正常组Eρ、AI、PWVβ及MMP-9水平均增高,AC降低,差异均有统计学意义(均P<0.05);内膜改变组β、Eρ、AI、PWVβ及MMP-9水平均增高,AC降低,差异均具有统计学意义(均P<0.05)。与内膜正常组比较,内膜改变组β、Eρ、PWVβ及MMP-9水平均增高,AC降低,差异均有统计学意义(均P<0.05)。内膜正常组血清MMP-9水平与Eρ、AC、PWVβ相关(r=0.375、-0.716、0.405,均P<0.05);内膜改变组血清MMP-9水平与Eρ、β、AC相关(r=0.616、0.381、-0.484,均P<0.05)。结论糖尿病患者颈动脉弹性指标与血清MMP-9水平相关,可作为糖尿病患者早期发现动脉粥样硬化病变的敏感指标。Objective To explore the correlation between the level of serum matrix metalloproteinase-9（MMP-9）and artery elasticity function in diabetic patients.Methods Thirty healthy volunteers were selected as normal control group,71 diabetic patients were enrolled and divided into two groups：31 diabetic patients with normal thickness of carotid artery intima（normal intima group）,40 diabetic patients with thickened intima or atheromatous plaque formation（endometrial change group）.The level of MMP-9 were measured by enzyme linked immunosorbent assay.The blood vessel elastic modulus,including carotid arterial stiffness（β）,pressure-strain elastic modulus（Eρ）,arterial compliance（AC）,increase index（AI） and pulse wave conduction velocity（PWVβ）were calculated by echo-tracking technique（ET）.Then the correlation between serum MMP-9 level and carotid artery elasticity parameters were analyzed.Results The value of Eρ,AI,PWVβ and the level of serum MMP-9 in normal intima group were higher than those in normal control group,while AC was lower than that in normal control group（all P0.05）.The value of β,Eρ,AI,PWVβ and the level of serum MMP-9 in endometrial change group were higher than those in normal control group,while AC was lower than that in normal control group（all P0.05）.The value of β,Eρ,PWVβ and the level of serum MMP-9 in endometrial change group were higher than those in normal intima group,while AC was lower than that in normal intima group（all P〈0.05）.The level of serum MMP-9 was related with Eρ,AC and PWVβ in normal intima group（r=0.375,-0.716,0.405,all P0.05）,and the level of serum MMP-9 was related with Eρ,β and AC in endometrial change group（r=0.616,0.381,-0.484,all P〈0.05）.Conclusion There is correlation between artery elasticity function and serum MMP-9 level in diabetic patients,the level of MMP-9 can be used as a sensitive index to detect the atherosclerosis in early stage.

关 键 词：超声检查 血管回声跟踪技术 颈动脉弹性 糖尿病 动脉粥样硬化 基质金属蛋白酶-9 

分 类 号：R587.1[医药卫生—内分泌] R445.1[医药卫生—内科学]