维吾尔族老年急性冠脉综合征患者血清胱抑素C、尿酸、血浆纤维蛋白原水平与冠脉病变程度的相关性  

Correlation of Cystatin C,Uric Acid and Fibrinogen with Lesion of Coronary Artery in Uygur Elderly Patients with Acute Coronary Syndrome

作　　者：古孜丽[1] 依力哈木·阿不力提甫 穆叶赛·尼加提[1] Gu Zili;Yilihamu · Abutilifu;Muyesai · Nijiati(Department o f Cardiology, The Xinjiang Uygur Autonomous Region People＇s Hospital,Xinjiang 830000 Chin)

机构地区：[1]新疆维吾尔自治区人民医院心内科,乌鲁木齐830000 [2]新疆医科大学研究生学院

出　　处：《医学研究杂志》2018年第4期35-38,182,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81160029);新疆维吾尔自治区自然科学基金资助项目(2015211C194)

摘　　要：目的 探讨新疆地区维吾尔族老年ACS患者血清胱抑素C、尿酸、血浆纤维蛋白原水平与冠脉病变严重程度的关系。方法 回顾性分析133例在新疆维吾尔自治区人民医院诊断考虑急性冠脉综合征并住院行冠脉造影的年龄≥65岁的维吾尔族患者的基本资料、既往史、生化指标。根据ACS组Gensini评分将患者分为低分组(0~29分)44例、中分组(30~59分)29例、高分组(≥60分)60例,比较ACS组胱抑素C、尿酸、血浆纤维蛋白原水平以及与Gensini评分的相关性。结果 随着Gensini评分增加,维吾尔族老年ACS患者血清胱抑素C、尿酸、血浆纤维蛋白原水平升高。Gensini评分与血清胱抑素C、尿酸、血浆纤维蛋白原水平均呈正相关(r分别为0.480、0.514、0.603,P均为0.000)。Logistic回归分析提示高血清胱抑素C、尿酸、血浆纤维蛋白原水平是高Gensini评分的独立危险因素。结论 维吾尔族老年ACS患者血清胱抑素C、尿酸、血浆纤维蛋白原水平升高与冠脉病变严重程度相关,是冠脉病变程度加重的危险因素,在临床工作中对维吾尔族老年ACS患者进行上述指标的检测,早期进行干预治疗,对预防急性冠脉事件的发生具有重要临床意义。Objective To investigate the relationship between the levels of serum cystatin C,uric acid,plasma fibrinogen and the severity of coronary lesions in Uygur elderly ACS patients in Xinjiang. Methods Retrospective analysis of 133 cases age≥65 years old Uygur patients basic information,past history,biochemical indicators which in the Xinjiang Uygur Autonomous Region People＇s Hospital to diagnose acute coronary syndrome and hospital coronary angiography was performed. According to the Gensini score,the patients were divided into low group（0-29 points） 44 cases,the middle group（30-59 points） 29 cases,high group（≥60 points） 60 cases,compared the cystatin C,serum Uric acid,plasma fibrinogen levels. Results With the increase of Gensini score,the levels of cystatin C,uric acid and plasma fibrinogen were increased in the Uygur elderly. Gensini scores were positively correlated with levels of cystatin C,uric acid and plasma fibrinogen（r = 0.480,0.514,0.603,all P = 0.000）. Logistic regression analysis showed that high serum Cystatin C,uric acid,and plasma fibrinogen levels were independent risk factors for high Gensini scores. Conclusion The levels of serum cystatin C,uric acid and fibrinogen in Uygur elderly ACS patients are related to the severity of coronary artery lesion,and are the risk factors of the severity of coronary artery lesion. It is important clinical significance for the prevention of acute coronary events to detect the above indicators and to intervene early in the Uygur elderly patients with ACS.

关 键 词：维吾尔族老年 急性冠脉综合征 血清胱抑素C 尿酸 血浆纤维蛋白原 冠脉病变程度 

分 类 号：R5[医药卫生—内科学]