地中海饮食在新诊断2型糖尿病男性患者勃起功能的保护作用及其机制  

Protective Effect and Its Mechanism of Mediterranean Diet on Erectile Function in Men with Newly Diagnosed Type 2 Diabetes Mellitus

作　　者：刘欢[1] 郭敏[1] 张希尧[1] 林颖慧[1] 田瑞飞 贾岳岳 Liu Huan;Guo Min;Zhang Xiyao(The Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang 150001 , China)

机构地区：[1]哈尔滨医科大学附属第四医院内分泌科,150001

出　　处：《医学研究杂志》2018年第4期77-81,共5页Journal of Medical Research

基　　金：黑龙江省卫生和计划生育委员会科研基金资助项目(2016-142)

摘　　要：目的 勃起功能障碍(erectile dysfunction,ED)是男性糖尿病患者常见的并发症。地中海饮食可以有效改善胰岛素敏感度,可能对糖尿病相关性ED起到保护或改善作用。本研究观察地中海饮食对于新诊断2型糖尿病男性患者的勃起功能的保护或改善作用,并探讨其可能的发生机制。方法 连续入组笔者医院门诊新诊断的男性2型糖尿病患者,随机分为3组,一组为低糖低脂饮食干预组,一组为地中海饮食干预组,一组为二甲双胍干预组,随访6个月。干预前后使用IIEF 5问卷评估勃起功能,并测定外周血氧化应激产物。结果 入组患者103例,平均年龄47.7±14.0岁,基线水平IIEF5评分在低糖低脂饮食干预组、地中海饮食干预组和二甲双胍干预组分别为13.7±6.5、14.2±5.0和13.9±7.7,IIEF 5评分与年龄、BMI、空腹血糖、糖化血红蛋白、胰岛素、胆固醇、吸烟水平相关。回归分析显示,校正上述因素后,血清MDA、SOD、NO仍是新发男性2型糖尿病患者勃起功能障碍的危险因素。与基线相比,地中海饮食组在干预6个月后IIEF 5评分改善明显(P<0.05),血糖水平改善明显(P<0.05),并与MDA、NO相关。结论 地中海饮食可以改善新诊断的男性2型糖尿病患者的阴茎勃起功能,可能是通过改善改善血清中氧化应激产物的水平实现的。地中海饮食可以在临床用于新诊断的2型糖尿病患者的生活方式干预。Objective To observe the effect of the Mediterranean diet on the protection or improvement of erectile function in newly diagnosed type 2 diabetic males and to explore its possible mechanism. Methods The newly diagnosed male type 2 diabetes mellitus was randomly divided into three groups. One group was the low-sugar and low-fat diet intervention group,one group was the Mediterranean diet intervention group,and one group was metformin intervention group,followed up for 6 months The before and after the intervention,the EE function was assessed using the IIEF 5 questionnaire and the oxidative stress products were measured. Results The median age was（47.7 ± 14.0） years and the baseline level IIEF5 score was 13.7 ± 6.5,14.2 ± 5.0 and 13. 9 ± 7.7. IIEF 5 in the low-sugar low-fat diet group,the Mediterranean diet intervention group and the metformin intervention group was associated with age,BMI,fasting blood glucose,glycosylated hemoglobin,insulin,cholesterol,smoking levels. Regression analysis showed that serum MDA,SOD and NO were still the risk factors of erectile dysfunction in newly diagnosed male type 2 diabetes mellitus after correction of the above factors. Compared with the baseline,the IIEF 5 score improved significantly（P〈0.05） in the Mediterranean diet group after 6 months of intervention,and the blood glucose level was significantly improved（P〈0.05）. Conclusion Mediterranean diets can improve the penile erectile function of newly diagnosed male type 2 diabetes patients and may be achieved by improving the level of oxidative stress products in the serum. Mediterranean diet can be used clinically for newly diagnosed type 2 diabetes patients lifestyle intervention.

关 键 词：地中海饮食 2型糖尿病 勃起功能 

分 类 号：R589[医药卫生—内分泌]