围化疗期针刺防治奥沙利铂神经毒性临床观察  

Clinical Observation of Acupuncture Prevention and Cure Effect on the Nitrobenzene Induced Neurotoxicity in the Circuit of Chemotherapy Period

作　　者：吴勇[1] 曾永蕾[1] 冷玉玲[1] WU Yong,ZENG Yonglei,LENG Yulin(The Second Affiliated Hospital of Anhui University of Chinese Medicine Anhui Hefei 230061, Chin)

机构地区：[1]安徽中医药大学第二附属医院针灸医院肿瘤科,安徽合肥230061

出　　处：《中医药临床杂志》2018年第4期725-728,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽省科技厅科技计划年度重点项目12070403075

摘　　要：目的:观察针刺防治奥沙利铂神经毒性的临床疗效,以及针刺对奥沙利铂化疗患者中医临床证候的影响。方法:将60例符合纳入标准的患者随机分为3组,针刺治疗组20例、西药对照组20例和单纯化疗组20例,所有患者均采用含奥沙利铂方案化疗,采用Levi感觉神经毒性评分评价治疗疗效,并观察中医临床证候变化。结果:针刺治疗组神经毒性发生率为30.00%,西药对照组发生率为36.84%,单纯化疗组发生率为78.95%,针刺治疗组与西药对照组均优于单纯化疗组,针刺治疗组与西药对照组差异比较无统计学意义(P>0.0167);三组神经毒性Levi分级比较,针刺治疗组与西药对照组神经毒性分级均低于单纯化疗组,差异具有统计学意义(P<0.05),针刺治疗组与西药对照组比较,差异无统计学意义(P>0.05);三组中医临床证候变化情况比较,针刺治疗组对奥沙利铂化疗患者的中医临床证候改善,优于西药对照组和单纯化疗组,差异比较具有统计学意义(P<0.05),而西药对照组与单纯化疗组比较,差异无统计学意义(P>0.05)。结论:针刺治疗可降低奥沙利铂神经毒性的发生及减轻神经毒性的反应程度,并能对化疗患者的中医临床证候有明显改善。Objective： To observe the clinical efficacy of acupuncture in preventing and treating neurotoxicity of oxaliplatin,and the effect of acupuncture on TCM clinical syndromes in patients receiving oxaliplatin chemotherapy. Methods：60 patients who met the inclusion criteria were randomly divided into 3 groups： 20 in the acupuncture treatment group, 20 in the western medicine control group, and 20 in the chemotherapy alone group. All patients were treated with oxaliplatincontaining chemotherapy, and Levi＇s sensory neurotoxicity score was used to evaluate the efficacy of the treatment and observe changes in TCM clinical syndromes. Results： The incidence of neurotoxicity was 30.00% in the acupuncture treatment group, 36.84% in the western medicine control group, and 78.95% in the chemotherapy alone group. Both the acupuncture treatment group and the western medicine control group were superior to the chemotherapy alone group.Acupuncture treatment There was no significant difference between the group and the western medicine control group（P〉0.0167）. The neurotoxicity grading of the three groups was lower than that of the chemotherapy group, and the difference was statistically significant（P〈0.05）. There was no significant difference between the acupuncture treatment group and the Western medicine control group（P〉0.05）. Comparing the changes of three groups of TCM clinical syndromes,the acupuncture treatment group had better clinical syndromes for patients with oxaliplatin chemotherapy than western medicine control group and chemotherapy alone group, and the difference was statistically significant（P〈0.05）. Western medicine control group and chemotherapy alone group, the difference was not statistically significant（P〉0.05）. Conclusion：Acupuncture treatment can reduce the occurrence of oxaliplatin neurotoxicity and reduce the degree of neurotoxicity response, and can significantly improve the TCM clinical syndromes of patients with chemotherapy.

关 键 词：针刺治疗 神经毒性 奥沙利铂 化学治疗 临床观察 

分 类 号：R246.5[医药卫生—针灸推拿学]