多奈哌齐联合美金刚治疗阿尔茨海默病的有效性及安全性系统评价  

The efficacy and safety evaluation of donepezil combined with memantine for the treatment of Alzheimer′s disease

作　　者：万素馨[1] 向毅[1] 罗亚玲 WAN Suxin;XIANG Yi;LUO Yaling(Chongqing Three Gorges Central Hospital , Chongqing , 404000 China;Department of Mathematics , School of Medical Information , Chongqing Medical University , Chongqing , 40016 China)

机构地区：[1]重庆三峡中心医院,重庆404000 [2]重庆医科大学医学信息学院数学教研室,重庆400016

出　　处：《药学实践杂志》2018年第3期260-264,281,共6页Journal of Pharmaceutical Practice

基　　金：中国社会科学基金(15BGL191)

摘　　要：目的采用系统评价的方法评估多奈哌齐联合美金刚治疗阿尔兹海默病(AD)的有效性和安全性,为临床用药提供参考。方法全面检索中国知网、万方、维普、中国生物医学文献等数据库,收集2014—2016年的相关文献,按纳入和排除标准进行文献筛选,采用Jadad量表进行质量评价,并用RevMan5.3软件进行数据处理。结果 18篇文献纳入本系统评价,均为随机对照研究,样本量1 796例(研究组900例,对照组896例)。研究组的简易精神状态量表(MMSE)、神经精神问卷(NPI)、痴呆病理行为评定量表(BEHAVE-AD)评价结果优于对照组,而日常生活功能量表(ADL)和阿尔茨海默病评价量表认知部分(ADAS-Cog)方面与对照组没有显著差异。结论研究组患者的精神状态、病理行为等方面有明显改善,治疗效果优于对照组。在临床应用中,应根据不同患者的具体病情来考虑用药方案。Objective To evaluate the efficacy and safety of donepezil combined with memantine in the treatment of Alzheimer′s disease and provide a guidance for the proper clinical use of those medications.Methods The literatures published from 2014 to 2016 in CNKI/VIP/WanFang Med-online/CBM and other databases were collected.Screening and quality evaluation were carried out with include and exclude standard.The software RevMan 5.3 was used for data analysis.Results Eighteen studies included are randomized controlled trials with 900 cases in study group and 896 cases in control group.The combined results showed that MMSE,NPI and BEHAVE-AD of the combination therapy were superior to those of monotherapy group.There is no significant difference in ADL and ADAS-Cog.Conclusion The combination therapy was better than monotherapy both in mental state and pathological behavior.The clinical application of those medications should be based on the specific conditions of individual patient.

关 键 词：多奈哌齐 美金刚 阿尔兹海默病 系统评价 

分 类 号：R971.5[医药卫生—药品]