血浆血小板反应蛋白-1水平与冠状动脉狭窄病变程度的关系研究  

Relationship between plasma TSP-1 and degree of coronary artery stenosis

作　　者：王竟悟 艾凤英[2] 王大胜 吴悠 苏岩杰 杨鑫泉 王大新 WANG Jingwu;AI Fengying;WANG Dasheng;WU You;SU Yanjie;YANG Xinquan;WANG Daxin(Clinical College o f Yangzhou University,Yangzhou, Jiangsu, 225001;Dalian Medical University, Dalian, Liaoning, 116044;The Second Xiangya Hospital of Central Souty University,Changsha, Hunan, 410011)

机构地区：[1]扬州大学临床医学院,江苏扬州225000 [2]大连医科大学,辽宁大连116044 [3]中南大学湘雅二医院,湖南长沙410011

出　　处：《实用临床医药杂志》2018年第9期6-10,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省"333"工程(BRA2015171);"六大高峰人才"(2014-SWYY-052)

摘　　要：目的探讨冠状动脉粥样硬化患者血浆血小板反应蛋白-1(TSP-1)水平变化及其与冠脉狭窄病变程度和血浆相关细胞因子的关系。方法选择因胸痛入院行冠状动脉造影检查的患者79例,根据冠状动脉造影结果对冠脉狭窄程度进行Gensini积分,根据积分结果分为低积分组27例、中积分组26例、高积分组26例;同时纳入造影结果正常者27例。采用酶联免疫法检测各组患者血浆TSP-1、超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-β_1(TGF-β_1)水平,分析TSP-1与冠脉狭窄程度即Gensini积分、hs-CRP、MMP-9、TGF-β_1的关系。结果 4组TSP-1水平比较,差异有统计学意义(P<0.05)。血浆中TSP-1的水平与相关细胞因子hs-CRP(r=0.4979,P<0.001)、MMP-9(r=0.3940,P<0.001)、TGF-β_1(r=0.4889,P<0.001)的水平存在显著相关性。多元逐步线性回归分析结果提示,冠状动脉狭窄的程度与血浆TSP-1水平存在关系。结论血浆TSP-1水平可做为冠状动脉狭窄程度的预测标记物。Objective To explore the change of of plasma TSP-1 level in patients with coronary atherosclerosis and its relationship with the degree of coronary artery stenosis and related plasma cytokines.Methods A total of 79 patients with chest pain were divided into low score group（n = 27）,medium score group（n = 26）,and high score group（n = 26） according to Gensini score.Another 27 normal controls were included as control group.The levels of plasma TSP-1,hs-CRP,MMP-9 and TGF-β_1 were detected by enzyme-linked immunoassay,and the relationship between TSP-1 and Gensini score,hs-CRP,MMP-9 and TGF-β_1 was analyzed.Results There were significant differences in level of plasma TSP-1 between four groups（P〈0.05）.The level of TSP-1 in plasma was correlated with hs-CRP（r = 0.4979,P〈0.001）,MMP-9（r = 0.3940,P〈0.001） and TGF-β1（r = 0.4889,P〈0.001）.The multiple stepwise linear regression analysis showed that there was a correlation between the degree of coronary artery stenosis and the plasma TSP-1 level.Conclusion Plasma TSP-1 level can be used as a biomarker for coronary stenosis.

关 键 词：血小板反应蛋白-1 动脉粥样硬化 GENSINI积分 冠状动脉狭窄 

分 类 号：R543.3[医药卫生—心血管疾病]