毛细支气管炎患儿血清25(OH)D和免疫球蛋白水平及干预性研究  

Serum levels of 25(OH) D and immunoglobulin in children with bronchiolitis and their intervention studies

作　　者：秦凯凯 马洪美[2] 王彬[1] 高涵 QIN Kaikai1, MA Hongmei2, WANG Bin1 , GAO Han1(1. Department of Pediatric, Weifang Medical University, Weifang 261053, China ; 2.Department of Pediatrics, the Affiliated Hospital of Weifang Medical Universit)

机构地区：[1]潍坊医学院儿科学教研室,山东潍坊261053 [2]潍坊医学院附属医院儿科

出　　处：《潍坊医学院学报》2018年第1期20-23,共4页Acta Academiae Medicinae Weifang

摘　　要：目的检测毛细支气管炎患儿血清25羟维生素D[25(OH)D]和免疫球蛋白(Ig A,Ig M,Ig G,Ig E)水平以及维生素D对该病干预治疗的效果。方法选取2016年1月~2016年12月在潍坊医学院附属医院儿科门诊就诊的6个月~12个月毛细支气管炎患儿218例,就诊时均抽取静脉血查血清25(OH)D及Ig A,Ig M,Ig G,Ig E水平,同时选取在门诊健康查体的相同年龄段婴儿98例为对照组,同样检测上述指标。给予218例毛细支气管患儿常规雾化吸入及对症支持治疗,同时根据血清25(OH)D水平,嘱其连续补充不同剂量的维生素D 6个月,6个月后对218例研究对象复诊,复诊时将严格遵医嘱补充维生素D者列为实验组(n=95),未正规补充者列为观察组(n=123),复查两组血清25(OH)D及Ig A、Ig M、Ig G、Ig E水平并进行比较,同时统计6个月内两组婴儿再发咳喘的概率。结果实验组和观察组治疗前血清25(OH)D,Ig A,Ig G水平低于对照组,Ig E水平高于对照组,差异均具有统计学意义(P<0.05);6个月后,实验组和观察组血清25(OH)D,Ig A,Ig M,Ig G水平均较治疗前升高,实验组升高更明显(Ig M除外),Ig E水平均较治疗前降低,实验组为著,比较差异均有统计学意义(P<0.05);随访观察6个月,实验组再患咳喘的概率(8.42%)明显低于观察组(24.39%),差异有统计学意义(P<0.05)。结论毛细支气管炎患儿大多存在维生素D不足和体液免疫功能紊乱,及时检测血清25(OH)D水平并正规补充维生素D可明显提升免疫功能,改善预后。Objective To detect serum 25（ OH） D and immunoglobulin（ Ig A,Ig M,Ig G,Ig E） levels in children with bronchiolitis and the interventional study of supply vitamin D. Methods Two hundred and eighteen cases of bronchiolitis in 6 - 12 months in the outpatient department of Pediatrics of the Affiliated Hospital of Weifang Medical University from January 2016 to December 2016 were selected. The serum levels of 25（ OH） D and Ig A,Ig M,Ig G and Ig E were extracted from venous blood. Meanwhile,98 children participated health physical examination at the same period were selected as the control group,and the above indexes were also detected. Two hundred and eighteen cases of bronchial children were given conventional inhalation and symptomatic treatment of symptomatic treatment. At the same time,according to the level of serum 25（ OH） D,it was ordered to supplement the different doses of vitamin D for 6 months. After6 months,218 subjects were treated with vitamin D supplementation as experimental group,and those who did not regularly supplement vitamin D were listed as observation group（ n = 123）. The levels of serum 25（ OH） D and Ig A Ig M Ig G Ig E in the two groups were reviewed and compared,and the probability of recurrent cough and asthma in the two groups was counted. Results Before treatment,the levels of serum 25（ OH） D,Ig A and Ig G in the experimental group and the observation group were lower than those in the control group,the level of Ig E was higher than that of the control group,the difference was statistically significant（ P〈0. 05）; After 6 months,the experimental group and observation group serum 25（ OH） D,Ig A,Ig M,Ig G levels were increased,the experimental group increased more significantly（ except Ig M）,Ig E decreased,the experimental group decreased more significantly,the difference was statistically significant（ P〈0.05）; within 6 months,the rate of wheezing in the experimental group（ 8. 42%） was lower than that in the observation group（ 24. 39%）,

关 键 词：毛细支气管炎 25(OH)D 免疫球蛋白 预后 

分 类 号：R722.13[医药卫生—儿科]