116例HIV抗体不确定结果阳转者的首次CD4^＋T淋巴细胞检测情况  

Analysis of the first CD4^ ＋ T lymphocytes counts test in sero-conversion of 116 cases with HIV antibodyindeterminate

作　　者：王尚博[1] 梁爽[1] 颜玉涛[1] 孙烨[1] 李春伟[1] 沈贞姬 巩雪[1] 梁笑天 刘岩琳[1] Wang Shangbo,Liang Shuang, Yah Yutao, Sun Ye, Li Chunwei, Shen Zhenji, Gong Xue, Liang Xiaotian , Liu Yanlin(Harbin Center for Disease Control and Prevention, Harbin 150056, Chin)

机构地区：[1]哈尔滨市疾病预防控制中心,150056

出　　处：《国际免疫学杂志》2018年第2期158-161,共4页International Journal of Immunology

基　　金：黑龙江省卫生计生委科研课题资助（2016-271）

摘　　要：目的通过对HIV抗体不确定结果阳转者的首次CD4＋T淋巴细胞（简称CD4细胞）检测情况分析，了解其免疫状态和疾病进展，为HIV抗体不确定结果阳转者的随访及干预工作提供依据。方法2010年1月至2017年4月期间，哈尔滨市116例首次WB HIV-1抗体不确定，经复检为HIV-1抗体阳性，分析其CD4细胞检测情况及相关因素。结果116例平均年龄（30.69±11.22）岁，最小16岁。男性占92.2%（107/116），未婚占72.4%（84/116），文化程度大专及以上占49.1%（57/116），传播途径为男男性行为占89.7%（104/116）。CD4细胞平均为（429.03±181.61）个/μL，最低44个/μL，CD4细胞〈500个/μL占65.1%（82/116）。按要求及时进行WB复检和CD4细胞检测的仅占29.3%（34/116）。结论116例HIV抗体不确定结果阳转者大部分已进入异常的免疫状态及不同程度的免疫抑制。对HIV抗体不确定者做好随访工作，告知按要求复检或增加复检频次，或进行核酸检测以缩短窗口期。对HIV抗体不确定结果阳转者及时进行CD4细胞检测。同时要提高医务人员的检测后咨询工作，使艾滋病的预防干预工作更为有效。ObjectiveTo understand the immune status and disease progression by analyzing the first CD4＋ T lymphocytes counts （CD4 cells）, and to provide the basis for the follow-up and intervention of HIV antibody indeterminate results which turn positive at later detection.MethodsFrom January 2010 to April 2017, the first test concerning CD4 cells and related factors of 116 sero-conversion cases with HIV antibody indeterminate in Harbin were retrospectively analyzed.ResultsAll 116 subjects show the average age of（35.80±9.64） years old with the youngest at 16 years old.Men accounted for 92.2% （107/116）, unmarried 72.4% （84/116）.49.1% （57/116） have college or higher than college education background.The first tested CD4 cells averaged at（429.03±181.61）/μL, with a minimum 44 /μL.CD4 cells 〈 500 /μL accounted for 65.1% （82/116）. Only 29.3% individuals were obcerued to have（34/116） WB reinspection and CD4 cell detection in time.ConclusionSero-conversion of 116 cases with HIV antibody indeterminate has entered an abnormal immune status with various levels of immunosuppression.Follow-up for peoples with HIV antibody indeterminate test result is important.They must be informed to have re-inspection, or to increase the frequency of re-inspection.In some cases, nucleic acid detection is required during the window period of HIV infection.More importantly, CD4 cell detection must be performed in time for sero-conversion cases with HIV antibody inderteminate test results.At the same time, the medical consultation should be improved to effectively prevent HIV infection.

关 键 词：人类免疫缺陷病毒 不确定结果阳转者 CD4细胞 

分 类 号：R512.91[医药卫生—内科学]