滋肾降糖丸对肾阴虚证2型糖尿病患者血清硬化蛋白的影响  

Zishen Jiangtang Pills Has Effect on Serum Sclerostin of Patients with Type 2 Diabetes Mellitus with Yin Deficiency of Kidney Syndrome

作　　者：渠昕[1] 楚淑芳[1] 赵恒侠[1] 刘德亮[1] 刘雪梅[1] 李金花[1] 李增英[1] 李惠林[1] QU Xin,CHU Shufang,ZHAO Hengxia,LIU Deliang,LIU Xuemei,LI Jinhua,LI Zengying,LI Huilin

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《新中医》2018年第5期51-54,共4页New Chinese Medicine

基　　金：深圳市科技计划项目(JCYJ20140408153331810)

摘　　要：目的:观察滋肾降糖丸对2型糖尿病患者糖代谢及血清硬化蛋白(SOST)的影响。方法:将60例2型糖尿病肾阴虚证患者随机分为2组各30例,观察2组患者基本情况、肾阴虚证证候积分、血糖等糖代谢指标及血清硬化蛋白水平。结果:治疗后,治疗组中医证候总积分低于对照组,治疗组降低空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、SOST及升高空腹C肽(FCP)效果分别与对照组比较,差异均有统计学意义(P<0.05)。结论:滋肾降糖丸可以明显降低肾阴虚证证候积分,改善临床症状,改善糖代谢,同时可以明显降低血清SOST水平。Objective：To observe the effect of Zishen Jiangtang pills on glucose metabolism and serum sclerostin（SOST）of patients with type 2 diabetes mellitus with yin deficiency of kidney syndrome. Methods：Divided 60 cases of patients with type 2 diabetes mellitus with yin deficiency of kidney syndrome into two groups randomly,30 cases in each group. Observed the basic condition,syndrome scores of yin deficiency of kidney syndrome,glucose metabolism indexes of blood glucose and so on, and level of serum sclerostin of patients in the two groups. Results： After treatment, Chinese medicine syndrome scores in the treatment group were lower than those in the control group,and the respective comparisons of the effect of fasting blood glucose（FBG）,fasting insulin（FINS）,glycosylated hemoglobin（HbA1c）,SOST and increase fasting C peptide（FCP） between the two groups showed significance in differences（P〈0.05）. Conclusion：Zishen Jiangtang pills can effectively decrease syndrome scores of yin deficiency of kidney syndrome, improve clinical symptoms and glucose metabolism,and obviously decrease level of serum SOST.

关 键 词：2型糖尿病 肾阴虚证 硬化蛋白 中药复方 

分 类 号：R587.1[医药卫生—内分泌]