小儿咳喘灵颗粒联合氨溴索口服液治疗儿童支气管肺炎临床观察  

Clinical Observation of Xiao'er Kechuanling Granules Combined with Ambroxol Hydrochloride Oral Liquid for Child Bronchopneumonia

作　　者：曹凤 CAO Feng

机构地区：[1]舟山市普陀区中医院,浙江舟山316100

出　　处：《新中医》2018年第5期134-137,共4页New Chinese Medicine

摘　　要：目的:观察小儿咳喘灵颗粒联合氨溴索口服液治疗儿童支气管肺炎的临床疗效。方法:将92例支气管肺炎患儿随机分为观察组和对照组各46例。对照组给予氨溴索口服液治疗,观察组在此基础上加用小儿咳喘灵颗粒,2组均连续治疗5天。观察2组临床疗效、症状体征消失时间和治疗前后血清炎症细胞因子[肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)]的变化。结果:观察组总有效率95.65%,对照组总有效率89.13%,2组比较,差异无统计学意义(P>0.05)。观察组肺部啰音、咳嗽、发热消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗前,2组TNF-α、hs-CRP、PCT水平比较,差异均无统计学意义(P>0.05)。治疗后,2组TNF-α、hs-CRP、PCT水平均较治疗前降低(P<0.05),观察组3项炎症细胞因子水平均低于对照组(P<0.05)。结论:小儿咳喘灵颗粒联合氨溴索口服液治疗小儿支气管肺炎,可明显缩短治疗时间,效果优于单纯使用氨溴索口服液。Objective：To observe the clinical effect of Xiao＇er Kechuanling granules combined with ambroxol hydrochloride oral liquid for child bronchopneumonia. Methods：Divided 92 cases of children with bronchopneumonia into the observation group and the control group randomly,46 cases in each case. The control group was given ambroxol hydrochloride oral liquid for treatment, while the observation group was additionally given Xiao＇er Kechuanling granules for treatment, and the treatment for both groups lasted for 5 days. Observed the clinical effect,time of the disappearance of symptoms and signs and changes of serum inflammatory cytokines [tumour necrosis factor-α（TNF-α）, high sensitive C-reactive protein（hs-CRP）,procalitonin（PCT）] in the two groups. Results：The total effective rate was 95.65% in the observation group and89.13% in the control group, difference being insignificant（P〈0.05）. The time of the disappearance of pulmonary rales,cough and fever in the observation group was shorter than that in the control group,differences being significant（P〈0.05）.Before treatment,there were no significant differences being found in the levels of TNF-α,hs-CRP and PCT of both groups（P〈0.05）. After treatment,the levels of TNF-α,hs-CRP and PCT of both groups were lower than those before treatment（P〈0.05）,and the levels of three indexes of inflammatory cytokines in the observation group were lower than those in the control group（P〈0.05）. Conclusion：Xiao＇er Kechuanling granules combined with ambroxol hydrochloride oral liquid for child bronchopneumonia can significantly reduce the treatment time, and its clinical effect is better than that treated with pure application of ambroxol hydrochloride oral liquid.

关 键 词：支气管肺炎 儿童 中西医结合疗法 小儿咳喘灵颗粒 氨溴索口服液 炎症细胞因子 

分 类 号：R563.12[医药卫生—呼吸系统]