独活寄生汤治疗膝骨关节炎临床疗效Meta分析  

Meta-analysis on Clinical Effect of Duhuo Jisheng Tang for Knee Osteoarthritis

作　　者：夏璇[1,2] 黄清春[2] 何羿婷[2] XIA Xuan,HUANG Qingchun,HE Yiting

机构地区：[1]广州中医药大学第二临床医学院,广东广州510120 [2]广东省中医院,广东广州510120

出　　处：《新中医》2018年第5期208-211,共4页New Chinese Medicine

基　　金：广东省中医药管理局课题(K20171136)

摘　　要：目的:探讨独活寄生汤治疗膝骨关节炎的临床疗效。方法:检索PubMed、Embase外文数据库及CNKI、万方、维普、CBM等中文数据库,纳入独活寄生汤治疗膝骨关节炎的随机对照试验(RCT)文献,用Cochrane系统评价手册进行质量评分,对总有效率和安全性进行Meta分析。结果:共纳入9篇RCT文献进入对照研究,Meta分析显示独活寄生汤治疗膝骨关节炎总疗效优于消炎止痛药[RR=1.35,95%CI(1.12,1.63),P=0.002<0.05],且副反应差异有统计学意义[RR=0.24,95%CI(0.13,0.47),P<0.01]。结论:独活寄生汤治疗膝骨关节炎较消炎止痛药有更好的临床疗效,且不良反应少,适合临床推广;但由于纳入文献质量不高,需要进一步开展高质量的随机对照研究。Objective：To explore the clinical effect of Duhuo Jisheng tang for knee osteoarthritis. Methods： Searched foreign language databases as PubMed and Embase and Chinese databases as CNKI,Wanfang, VIP, CBM and so on.Randomized controlled trials（RCT） literature of Duhuo Jisheng tang for knee osteoarthritis was brought into the analysis. The quality score was carried out by Cochrane system evaluation manual and the meta-analysis was conducted to analyze the total effective rate and safety. Results： Nine pieces of RCT literature were included in the control study. Meta-analysis showed the total curative effect of Duhuo Jisheng tang for knee osteoarthritis is superior to that of anti-inflammatory analgesics [RR=1.35,95%CI（1.12,1.63）,P=0.0020.05] and the differences in side effects were significant [RR=0.24,95%CI（0.13, 0.47）, P〈0.01]. Conclusion：Duhuo Jisheng tang has better clinical effect than anti-inflammatory analgesics in treating knee osteoarthritis,which has less adverse reactions,being suitable for clinical popularization. However,due to the low quality of the literature,it is necessary to carry out further randomized controlled studies of high quality.

关 键 词：膝骨关节炎 独活寄生汤 消炎止痛药 META分析 

分 类 号：R684.3[医药卫生—骨科学]