生物可完全降解封堵器封堵犬卵圆孔未闭的实验研究  

Animal experimental study of the fully biodegradable patant foramen ovale(PFO) occluder

作　　者：谢航 杨濛 成革胜[1] 张婷婷 杜亚娟[1] 何璐[1] 张玉顺[1] XIE Hang, YANG Meng, CHENG Ge-sheng, ZHANG Ting-ting, DU Ya-juan, HE Lu, ZHANG Yu-shun(Department of Structural Heart Disease, First Affiliated Hospital, Xi ＇an Jiaotong University, Xi＇an 710061, Shaanxi, Chin)

机构地区：[1]西安交通大学第一附属医院结构性心脏病科,陕西西安710061

出　　处：《心脏杂志》2018年第3期270-273,共4页Chinese Heart Journal

基　　金：陕西省科技统筹创新工程计划项目资助(2014KTCL03-11)

摘　　要：目的评估生物可完全降解卵圆孔未闭(patent foramen ovale,PFO)封堵器封堵犬PFO的可行性、安全性等。方法右胸小切口开胸卵圆窝穿刺法建立犬PFO模型,即刻在直视及经胸超声心动图(TTE)引导下用生物可完全降解型PFO封堵器封堵PFO。在植入后分别于1、3、6、9和12个月各处死2只犬,进行肉眼和组织学检查。结果10只犬成功建立PFO模型后并植入可完全降解PFO封堵器。随访见封堵器均未发生移位,表面无赘生物及血栓形成,大体解剖见内膜组织从边缘逐渐完全覆盖封堵器表面。组织病理学提示,术后6个月封堵器骨架几乎完全降解并和周围组织融为一体。结论应用生物可完全降解PFO封堵器封堵犬PFO,降解后在体内无任何残留物,是一种安全、有效并且可行的封堵器。AIM To evaluate the feasibility, safety of a fully biodegradable occluder for closure of patent foramen ovale （PFO） in an acute canine model. METHODS The PFO was created in healthy canine by a homemade PFO perforator and the PFO was closed immediately by the fully biodegradable PFO occluder. Animals were sacrificed at 1,3, 6, 9 and 12 months after procedure. RESULTS Acute PFO models were successfully created in 10 dogs and occluders was successfully implanted in the PFO model. The cardiac gross anatomy revealed that all occluders were stable in the fossa ovale and no vegetation or thrombosis formation was observed on the surface of all occluders. The endothelial tissue gradually covered from the edge of the surface of occluder. Different periods of pathological observations suggested that tile skeleton of occluder is almost completely degraded and integrated with the host tissue at 6 month follow-up CONCLUSION The present investigation model and no residue was identified in the method of closing the PFO and the efficacy applied fully biodegradable occluder to close PFO in a canine body after degradation. This is a safe, effective and feasible was similar when compared to a metal occluder.

关 键 词：封堵器 生物可降解 卵圆孔未闭 犬 

分 类 号：R541.1[医药卫生—心血管疾病]