心外膜脂肪对冠心病的影响及干预进展  

Recent advances in effect of epicardial adipose tissue on coronary atherosclerosis disease and its intervention

作　　者：单冬凯[1] 刘昱圻[1] 陈韵岱[1] SHAN Dong-kai, LIU Yu-qi, CHEN Yun-dai(Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, Chin)

机构地区：[1]中国人民解放军总医院心血管内科,北京100853

出　　处：《心脏杂志》2018年第3期340-343,354,共5页Chinese Heart Journal

基　　金：国家重点研发计划项目资助(2016YFC1300300)

摘　　要：心外膜脂肪组织(EAT)是围绕在心脏和冠状动脉周围的特殊内脏脂肪组织。近年来研究发现,EAT是内源性脂肪和促炎因子的重要来源,可调节冠状动脉粥样硬化性心脏病的发生和发展过程。本文回顾了EAT与冠状动脉粥样硬化性心脏病相关的最新研究进展,并对以EAT为干预靶点,发挥治疗冠心病潜能的相关研究进行综述。Epicardial adipose tissue, a special visceral adipose tissue surrounding the heart and coronary arteries, recently has been found to be an important source of endogenous adipokines and proinflammatory cytokines. It may be involved in the presence and pathophysiological progress of coronary atherosclerosis disease. This review briefly summarizes recent advances in the relationship between epicardial adipose tissue and coronary atheroselerosis disease and reviews the potentials of epicardial adipose tissue serving as a target for intervention of atheroselerosis.

关 键 词：心外膜脂肪组织 冠状动脉粥样硬化性心脏病 脂肪因子 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]