槐杞黄辅助治疗哮喘儿童疗效及外周血中Th1 Th2相关细胞因子 对氧磷酶1水平的影响  

Clinical efficacy of Huaiqihuang granule in the treatment of children with bronchial asthma and its effects on the level of cytokines Th1, Th2 and PON1

作　　者：贾春梅[1] 王冬梅[1] 宁立华 姜采荣[1] 楚文英[1] 曲艳杰[1] 王俊卿[1] JIA Chun-mei, WANG Dong-mei, NING Li-hua, et al.(Department of Pediatrics ,the Fourth Hospital of Baotou ,Baotou 014030, Chin)

机构地区：[1]内蒙古自治区包头市第四医院儿科,内蒙古包头014030

出　　处：《中国实用儿科杂志》2018年第5期365-369,共5页Chinese Journal of Practical Pediatrics

基　　金：内蒙古自治区应用技术研究与开发资金计划项目(201702139)

摘　　要：目的研究槐杞黄颗粒对哮喘患儿的辅助治疗作用,以及其对外周血中Th1、Th2相关细胞因子、对氧磷酶1(PON1)水平的影响。方法将2014年6月至2015年6月内蒙古自治区包头市第四医院收治的符合哮喘诊断标准的180例患儿随机分为研究组(96例)和常规组(84例),设定正常对照组(50例)。两组哮喘患儿均给予规范化哮喘基础治疗,研究组同时给予槐杞黄治疗3个月。比较两组哮喘患儿治疗前1个月、治疗后第1个月、第3个月及第6个月呼吸道感染次数、喘息发作次数、应用急救药物次数、因喘息住院次数,并比较治疗前及治疗后3个月的相关细胞因子水平变化。结果治疗后,上呼吸道感染次数、支气管炎和肺炎、喘息发作次数、应用急救药物次数和因喘息住院次数较治疗前均明显减少(P<0.05)。治疗前、后白介素-4(IL-4)、白介素-13(IL-13)、白介素-12(IL-12)、干扰素-γ(IFN-γ)和PON1水平变化差异均有统计学意义(P<0.01)。结论槐杞黄颗粒辅助治疗哮喘,能够减少呼吸道感染及喘息发作的次数,帮助提高临床治疗效果;可能通过降低外周血中Th2相关细胞因子(IL-4、IL-13)水平,提高Th1相关细胞因子(IL-12、IFN-γ)以及PON1水平,发挥治疗哮喘的作用。Objective To observe the clinical efficacy of Huaiqihuang in the treatment of children with bronchial asthma and its effects on the level of cytokines Th1, Th2 and PON 1. Methods A total of 180 children with bronchial asthma admitted between June 2014 and June 2015 in the Fourth Hospital of Baotou were randomized into the observation group （96 cases of GINA regimen treatment combined with Huaiqihuang）and the GINA regimen treatment group （84 cases）, healthy children were enrolled as control group （50 cases）. Times of respiratory tract infection occurrence, asthmatic attacks, application of emergency medicine, hospitalization due to asthmatic and the levels of IL-4, IL-12, IL-13, INF-γand PON1 were observed before and after treatment. Results There were significant differences about the times of upper respiratory tract infections, bronchitis and pneumonia, asthma attacks, application of emergency medicine and hospitalization due to asthmatic （P 〈 0.05 ）. There were significant differences about the changes of IL-4, IL-12, IL-13, INF-γ and PON1 before and after treatment （P 〈 0.01 ）. Conclusion The treatment of bronchial asthma in children with Huaiqihuang granule can reduce the incidence of respiratory infections and the number of asthmatic attacks and improve clinical effect. The Huaiqihuang granule alleviating asthma symptoms may by decreasing the levels of Th2 cytokines （IL-4, IL-13 ）and also by increasing the levels of Th 1 cytokines （IL-12, IFN-γ）and PON1.

关 键 词：槐杞黄颗粒 支气管哮喘 儿童 对氧磷酶1 

分 类 号：R72[医药卫生—儿科]