一个基于席夫碱配体的Mn(Ⅱ)配合物的合成、结构表征及体外抗多重耐药白色念珠菌的活性研究  

A new Mn(Ⅱ) complex based on Schiff base ligand:Synthesis,structure and in vitro antifungal activity against clinical multi-drug resistant Candida albicans

作　　者：杨君如 余巍 朱玉婷 李方芳[1] 赵琦华[1] 谢明进[1] YANG Jun-ru1, YU Wei1,2 , ZHU Yu-ting2 , LI Fang-fang1 , ZHAO Qi-hua1 , XIE Ming-jin1(1. School of Chemical Science and Technology, Yunnan University, Kunming 650091, China ; 2.Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, Chin)

机构地区：[1]云南大学化学科学与工程学院,云南昆明650091 [2]解放军昆明总医院药学部,云南昆明650032

出　　处：《云南大学学报（自然科学版）》2018年第3期529-537,共9页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金(21161022);云南省中青年学术技术带头人后备人才项目(2011CI002)

摘　　要：以N,N’-邻羟亚苄基-4,5-二甲基邻苯二胺为配体合成一个新型Schiff-base Mn(Ⅱ)配合物,通过红外、单晶衍射对其进行了结构表征.用琼脂扩散法测定Mn(Ⅱ)配合物对临床分离耐药真菌的抑菌圈大小,微量稀释法测定配合物对上述菌株的最低抑菌浓度[minimum inhibitory concentration(MIC)]、最低杀细菌浓度[minimum bactericidal concentration(MBC)].抑菌试验结果表明,Mn(Ⅱ)金属配合物对一般临床分离真菌白念592、白念103和耐氟康唑临床分离真菌白念Z2901、白念Z2503和白念649具有良好的抑菌效果,其与氟康唑联合对抑制白念649和白念Z2901具有有协同杀菌作用.A new Mn（ Ⅱ） complex with a Schiff base,N,N＇-bis-salicylidene-4,5-dimethyl-phenylendiamine as the ligand,has been prepared and structurally characterized by X-ray crystal diffraction and IR.Its antimicrobial activity was evaluated by AGAR diffusion method against different Candida albican strains resistant to several antibacterial drugs.The minimum inhibitory concentration（ MIC） and minimum bactericidal concentration（ MBC） were determined by serial dilution method with a standard broth microdilution.The results indicated that Mn（ Ⅱ） complex show significant activity against C.albicans 592 and C. albicans 103 and fluconazole-resistant clinical isolates C.albicans Z2901,C.albicans Z2503,C.albicans 649.Moreover,the synergistic antibacterial effect can be achieved between the Mn（ Ⅱ） complex and fluconazole against C.albicans 649 and C.albicans Z2901.

关 键 词：SCHIFF-BASE Mn(Ⅱ)配合物 白色念珠菌 抗菌活性 

分 类 号：O627.23[理学—有机化学]