长药八宝中酚酸类化合物的分离和含量测定  

Isolation and Content Determination of Phenolic Acids in Hylotelephium Spectabile(Bor.) H.Ohba

作　　者：尹秀梅[1] 张敬东[2] 金慧娟[3] 王思宏[2,3] 李东浩[3] YIN Xiu-mei 1 , ZHANG Jing-dong 2 , JIN Hui-juan 3 , WANG Si-hong 2,3 , LI Dong-hao 3(1. College of Pharmacy, 2. Analysis and Inspection Center, 3. Key Laboratory of Natural Resource of the Changbai Mountain and Functional Molecules, Ministry of Education,Yanbian University, Yanji 133002, China)

机构地区：[1]延边大学药学院,吉林延吉133002 [2]延边大学测试中心,吉林延吉133002 [3]延边大学长白山生物资源与功能分子教育部重点实验室,吉林延吉133002

出　　处：《化学试剂》2018年第5期442-444,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(21365023)

摘　　要：长药八宝（Hylotelephium spectabile（Bor.）H.Ohba）是耐旱的观赏植物,其全草药用。采用硅胶柱层析,首次对长药八宝中的酚酸类的化学成分进行了分离,分离出反式对羟基肉桂酸、顺式对羟基肉桂酸、异香草酸、对羟基苯甲酸和没食子酸5种化合物。采用紫外光谱法对长药八宝中的反式对羟基肉桂酸、对羟基苯甲酸和没食子酸进行了定量研究。酚酸类成分是高效潜在的天然抗氧化剂,该研究成果将为天然产物的开发与利用以及新药的研制提供数据参考。Hylotelephium spectabile（Bor.） H.Ohba is a drought resistant ornamental plant,and its whole herb is used as medicine.The chemical composition of Hylotelephium spectabil（Bor.） H.Ohba was investigated by means of silica gel column chromatography for the first time,5 kinds of phenolic acids,such as trans p-hydroxy cinnamic acid,cis p-hydroxy cinnamic acid,isovanillic acid,p-hydroxybenzoic acid,gallic acid were isolated.The content of trans p-hydroxy cinnamic acid,p-hydroxybenzoic acid and gallic acid were determined by ultraviolet spectroscopy.These substances are the basis for the antioxidation of Hylotelephium spectabil（Bor.） H.Ohba.Phenolic acids are high potential natural antioxidants.The result will provide data reference for the development and utilization of natural products as well as the development of new drugs.

关 键 词：长药八宝 酚酸类化合物 分离 波谱测定 紫外光谱 含量测定 

分 类 号：R284.1[医药卫生—中药学]