银翘散联合抗病毒治疗干预甲型流感的疗效及与血清转化生长因子β1(TGFβ1)水平变化的关联分析  

Effect of Yinqiao Powder Combined with Antiviral Therapy on Influenza A and Influence on Level of Serum Transforming Growth Factor β1

作　　者：陶蕾 徐爱晖[1] TAO Lei,XU Aihui(Department of Respiration, The First Affiliated Hospital of Medical University of Anhui, Hefei 230000, Anhui, Chin)

机构地区：[1]安徽医科大学第一附属医院呼吸科

出　　处：《中华中医药学刊》2018年第5期1116-1118,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家公益性科研专项项目(201302003)

摘　　要：目的：分析银翘散联合抗病毒治疗干预甲型流感的疗效及与血清转化生长因子β1水平变化的关联。方法：研究回顾性选取甲型流感患者127例进行研究,其中60例接受了银翘散联合抗病毒治疗,为观察组患者;67例接受常规抗病毒治疗,为对照组。比较两组患者治疗效果,并测定血清TGF-β1水平进行分析比较。研究使用SPSS 18.0软件分析数据。结果：研究中,治疗后观察组疗效优于对照组,观察组患者体温恢复正常的时间平均为（6.98±1.08）d,对照组为（9.86±1.84）d;扁桃体恢复正常的时间为（8.69±2.80）d,对照组为（13.29±2.65）d;而咽部充血恢复正常的时间两组分别为（10.51±2.74）d以及（16.66±2.88）d;观察组血象恢复的时间则为（9.31±2.50）d,而对照组为（15.02±2.94）d。表明在体温恢复时间、扁桃体回复时间以及咽部充血恢复正常时间和血象恢复正常时间上观察组均低于对照组,且差异有统计学意义,P〈0.05。比较分析了治疗前后两组患者血清TGF-β1表达的变化,可见治疗前观察组和对照组患者的TGF-β1水平分别为（47.93±13.07）ng/mL和（47.55±11.94）ng/mL;治疗后观察组患者TGF-β1水平增高至（67.69±12.54）ng/mL,对照组患者的TGF-β1水平则增高至（51.89±12.61）ng/mL。治疗前两组患者TGF-β1水平差异未见统计学意义,治疗后两组TGF-β1水平均高于治疗前,差别均有统计学意义,P〈0.05;且治疗后观察组水平显著高于对照组,P〈0.05。结论：甲型流感患者存在肺损伤等病理表现,可见血清TGF-β1水平减低,并于治疗后增高;而银翘散联合抗病毒治疗明显具有更优的治疗效果。Objective： To analyze the effect of Yinqiao Powder combined with antiviral therapy on influenza A and the relationship with the changes of serum transforming growth factor β1 in patients. Methods： Sixty-seven patients with influenza A were retrospectively selected. Sixty patients underwent anti-viral treatment with Yinqiao Powder and micro-observation group. Sixty-seven patients were treated with conventional antiviral therapy as the control group. The therapeutic effect of the two groups was compared and the levels of serum TGF-β1 were analyzed and compared. The data was analyzed using SPSS 18. 0 software. Results： The observation group was better than the control group. The time of body tempareture recovery was（6. 98 ± 1. 08） days in the observation group and（9. 86 ± 1. 84） days in the control group. The time of normal recovery of tonsils was（8. 69 ± 2. 80） days in the observation group and the control group＇s was（13. 29 ± 2. 65） days. The recovery time of pharyngeal hyperemia of the observation and control groups was（10. 51± 2. 74） days and（16. 66 ± 2. 88） days,respectively. The recovery time of blood samples in the observation group was（9. 31 ± 2. 65） days and the control group＇s was（15. 02 ± 2. 94） days. The results showed that there was significant difference of the time of recovery of body temperature,the recovery time of tonsil and the time of recovery of pharyngeal hyperemia and the normal time of blood resuscitation in the two groups,and the difference was statistically significant（P〈0. 05）. TGF-β1 levels in the observation and the control groups were（47. 93 ± 13. 07） ng/mL and（47. 55 ±11. 94） ng/mL,respectively. The level of TGF-β1 in the observation group was increased to（67. 69 ± 12. 54） ng/mL after treatment,and that in the control group was increased to（51. 89 ± 12. 61） ng/mL. There was no significant difference in the level of TGF-β1 between the two groups before treatment,and the levels of TGF-β1 in the two groups w

关 键 词：银翘散 抗病毒治疗 甲型流感 转化生长因子β1 

分 类 号：R373.13[医药卫生—病原生物学]