血管性痴呆相关危险因素研究进展  

Research Progress on Risk Factors of Vascular Dementia

作　　者：赵霄潇 李慧生[2] 王宏宇[1] ZHAO Xiaoxiao;LI Huislieng;WANG Hongyu(Department of Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China;Paking University People＇s Hospital,Beijing 100044,China)

机构地区：[1]北京大学首钢医院,北京100144 [2]北京大学人民医院,北京100044

出　　处：《心血管病学进展》2018年第3期328-331,共4页Advances in Cardiovascular Diseases

基　　金：国家重点研发计划(2017YFC0113000);北京中医药科技发展资金项目(NQ2016-07);北京大学首钢医院院内临床重点项目(2017-院-临床-01);北京大学首钢医院院内基金(SGYYQ201605);北京大学首钢医院院内临床重点项目(SGYYZ201610)

摘　　要：血管性痴呆是以缺血缺氧性或出血性脑损伤造成的病理组织学损伤和进行性智能减退为特征的疾病,是仅次于阿尔茨海默病的第二大痴呆类型。因此,血管性痴呆实际上是一系列由于血管因素引起的痴呆综合征,临床以多发性脑梗死性痴呆较多见。该病与高血压、脂质紊乱、动脉硬化、高同型半胱胺酸、心脏病、糖尿病、脑卒中和短暂性脑缺血发作、ASA-PD基因有密切关系。目前,血管性痴呆是唯一一种可以防治的痴呆,故对血管性痴呆危险因素和发病机制的研究具有重要临床意义。Vascular dementia（VD） is a disease characterized which caused by pathological damage by decreased intelligence in hypoxic ischemic or hemorrhagic brain inj ury. It is the second only to Alzheimer＇s disease as one of the major types of dementia. Therefore,VD is actually a series of dementia syndrome caused by vascular factors. Multi-infarct dement ia are more common in clinic. The disease has a close relationship with hypertension, dyslipidemia, atherosclerosis, high homocysteine, heart disease, diabetes,stroke and transient ischemic attack, and the ASA-PD gene. At present,VD is the only type of dementia which can be prevented an cured. The study on risk factors and pathogenesis of VD has important clinical significance.

关 键 词：血管性痴呆 危险因素 血管病变 

分 类 号：R543[医药卫生—心血管疾病] R741[医药卫生—内科学]