精神心理障碍及下丘脑-垂体-肾上腺轴对冠心病的影响  

Effects of Mental Disorders and Hypothalamic-pituitary-adrenal Axis on Coronary Heart Disease

作　　者：苏瑞[1] 肖践明[1] 张敏[1] SU Rui;XIAO Jianming;ZHANG Min(Departmentof Cardiology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,Chin)

机构地区：[1]昆明医科大学第一附属医院心内科,云南昆明650032

出　　处：《心血管病学进展》2018年第3期370-374,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金资助项目(81360040);云南省科技厅-昆明医科大学应用基础联合专项基金资助项目(2013FB140);美国雅礼协会贾氏家庭健康基金资助项目(2011CF04)

摘　　要：下丘脑-垂体-肾上腺轴是神经内分泌系统的重要组成部分,下丘脑-垂体-肾上腺轴及其产物是参与中枢神经系统调节免疫系统的主要枢纽。最近越来越多证据表明下丘脑-垂体-肾上腺轴功能失调可能是精神心理障碍引起冠心病的主导机制。现综述精神心理障碍中下丘脑-垂体-肾上腺轴功能失调对冠心病的影响及相关机制的研究进展,以期在临床工作中应对这类多学科交叉疾病,提供新的思路。The hypothalamic-pituitary-adrenal（HPA） axis is an important component of the neuroendocrine system. The HPA axis and its products are a major hub for the central nervous system to regulate the immune system. Recently ,increasing research shows that the dysfunction of HPA axis is linked to mental disorders and coronary heart disease. This paper reviews the development of the correlation between dysfunction of HPA axis and coronary heart disease ,to provide newp erspectives on multidisciplinary diseases in clinical work.

关 键 词：冠心病 精神心理障碍 下丘脑-垂体-肾上腺轴 

分 类 号：R541.4[医药卫生—心血管疾病] R749.24[医药卫生—内科学]