A类清道夫受体参与动脉粥样硬化形成的机制  

Mechanism of Scavenger Receptor-A in Atherosclerosis

作　　者：刘静[1] 高森[1] 赵鹃[1] LIU Jing;GAO Sen;ZHAO Juan(Department of Cardiology,The First Affiliated Hospital,Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2018年第3期456-459,共4页Advances in Cardiovascular Diseases

基　　金：国家自然基金(81301276)

摘　　要：A类清道夫受体是单核巨噬细胞表面的一种跨膜糖蛋白的三聚体,调节巨噬细胞内脂质沉积,参与动脉粥样硬化斑块的形成。现综述且整理相关A类清道夫受体的最新进展,通过炎症调控、内质网应激、巨噬细胞由M1向M2型转化以及胰岛素抵抗等途径,阐明A类清道夫受体在动脉粥样硬化形成中的作用,同时简述了饮食及药物对A类清道夫受体水平的影响。Scavenger receptor A（SR-A） is a trimer of membrane glycoproteins on the surface of monocyte/macrophage, which regulates lipid accumulation in macrophage and participates in the formation of atherosclerotic plaques . The review focuses on the role of SR-A through the regulation of inflammation,endoplasmic reticulum stress,the transformation of M1 macrophages to M2 macrophages and insulin resistance in the development of atherosclerosis, and then ,we outline the effects of diet and the drugs on SR-A levels.

关 键 词：动脉粥样硬化 A类清道夫受体 巨噬细胞 

分 类 号：R54[医药卫生—心血管疾病]