艰难梭菌感染实验室诊断的研究进展  

Progress of laboratory diagnosis of Clostridioides difficile infection

作　　者：杨靖[1] 赵建宏[1] Yang Jing;Zhao Jianhong(Center of Hebei Provincial Medical Laboratory,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Chin)

机构地区：[1]河北医科大学第二医院河北省临床检验中心,河北石家庄050000

出　　处：《临床荟萃》2018年第5期373-376,共4页Clinical Focus

基　　金：河北省重点研发计划项目(国际科技合作专项;183977118D);河北省自然科学基金资助项目(2013206450)

摘　　要：艰难梭菌是一种专性厌氧革兰阳性芽孢杆菌,一般认为是环境和人类肠道中的正常菌群。过度应用抗生素、免疫抑制剂或化疗药物使耐药的艰难梭菌产毒株过度繁殖并释放毒素是导致艰难梭菌感染(Clostridioides difficileinfection,CDI)的主要因素。CDI的发病率在全球范围内不断增加,尤其是高产毒株在北美地区造成了医院内的暴发流行,引起了世界范围的关注。在此对艰难梭菌的致病机制和实验室诊断方法的研究进展进行阐述,为艰难梭菌相关性腹泻的早期诊断和治疗提供新思路。Clostridioides difficile is a gram-positive,anaerobic spore-forming bacillus commonly found in the environment and human gut.Over use of antibiotics,immunosuppressive agents and chemotherapy drugs all may lead to the overgrowth of the toxic strain of C.difficile with high resistance,which is the main factor responsible for C.difficile infection（CDI）.The globally increasing incidence of CDI,especially the outbreak of nosocomial infection caused by the hypervirulent strain in North America,has aroused worldwide attention.To provide new insights into the early diagnosis and treatment of diarrhea associated with C.difficile,this review summarizes the latest development on pathogenesis and laboratory diagnosis of C.difficile.

关 键 词：梭菌感染 诊断 

分 类 号：R517.5[医药卫生—内科学]