蜱传脑炎病毒感染引发细胞信号转导的研究进展  

Progress of cellular signaling transduction triggered by tick-borne encephalitis virus

作　　者：唐海琳[1] 张龙严[1] 赵兰娟[1] TANG Hailin;ZHANG Longyan;ZHAO Lanjuan(Department of Microbiology, Second Military Medical University, Shanghai 200433, Chin)

机构地区：[1]第二军医大学微生物学教研室,上海200433

出　　处：《生命的化学》2018年第2期303-308,共6页Chemistry of Life

基　　金：国家重点研发计划项目(2016YFC1202903);上海市公共卫生三年行动计划重点学科建设项目(15GWZK0103)

摘　　要：人类高致病性虫媒传播蜱传脑炎病毒(tick-borne encephalitis virus,TBEV)是蜱传脑炎的重要病原体,疾病表现为伴有或不伴有脊髓炎的急性脑膜炎。TBEV在自然界中的生存依赖于硬蜱和野生脊椎动物宿主。最近30年,TBEV在全球的地理分布呈持续扩张趋势。报道认为,TBEV感染所致细胞异常信号转导是病毒致病的分子机制。文章综述了TBEV感染引发细胞信号转导事件及其与病毒致病机制的关联。Tick-borne encephalitis virus（TBEV）, endemic and highly pathogenic for humans, is an important arthropod-borne pathogen that causes tick-borne encephalitis. It is known that TBEV infection causes acute meningoencephalitis with or without myelitis. TBEV is maintained in ticks and wild vertebrate hosts in the nature. Over the last 30 years, the geographical distribution of TBEV has continuously expanded worldwide. Disturbance of cellular signal transduction by TBEV infection is involved in elucidating the molecular mechanisms of viral pathogenicity. In this article, the cellular signaling events triggered by TBEV and their implications for TBEV pathogenesis were reviewed.

关 键 词：蜱传脑炎病毒 蜱传脑炎 信号转导 致病机制 

分 类 号：R373.31[医药卫生—病原生物学]