布拉酵母菌联合乳果糖对儿童功能性便秘患者血清脑肠肽的调节作用  

Regulatory effect of Saccharomyces boulardii combined with Lactulose on serum brain-gut peptides in children with functional constipation

作　　者：杨艳君 YANG Yanjun(Department of Paediatrics, the Second People＇s Hospital of Pujiang, Pujiang, Zhejiang 322204, Chin)

机构地区：[1]金华市浦江第二医院儿科,浙江浦江322204

出　　处：《中国微生态学杂志》2018年第4期441-443,447,共4页Chinese Journal of Microecology

摘　　要：目的探讨布拉酵母菌联合乳果糖对儿童功能性便秘(FC)患者血清脑肠肽的调节作用。方法选取金华市浦江第二医院儿科门诊治疗的儿童FC患者92例,随机分为观察组和对照组各46例。两组患儿均常规给予饮食调整和加强排便功能锻炼等基础治疗。观察组患儿采用乳果糖口服液(5mL/次,2次/d,口服)联合布拉酵母菌散剂(0.25g/次,1次/d,温开水冲服)治疗。对照组患儿只给予单纯的乳果糖口服液治疗,剂量、方法与疗程同观察组,两组患儿均连用8周。观察两组患儿治疗前后血清脑肠肽指标[P物质(SP)和神经降压素(NT)]水平的变化,并评估其临床治疗效果及随访半年的复发率。结果治疗8周后,两组患儿血清SP和NT水平均明显上升,且观察组上述指标上升幅度更大(P<0.05);同时观察组患儿临床总有效率高于对照组(χ~2=4.04,P<0.05)。对治疗有效者随访半年,观察组患儿的复发率明显低于对照组(χ~2=4.85,P<0.05)。结论布拉酵母菌联合乳果糖治疗儿童FC患者效果肯定,能降低患儿复发率,其作用机制可能与其能升高血清SP和NT水平,促进肠道蠕动密切相关。Objective To discuss the regulatory effect of Saccharomyces boulardii combined with Lactulose on serum brain-gut peptides in children with functional constipation（FC）.Methods 92 children with FC collected by department of Paediatrics of the Second People′s Hospital of Pujiang were divided into observation group（46 cases）or control group（46 cases）at random.All the children were given the same basic treatment.The children in observation group were additionally given Lactulose oral liquid（5 mL b.i.d）combined with Saccharomyces boulardii Powder（0.25 g,qd,orally）,while those in control group were given Lactulose oral liquid alone;All children were treated for 8 weeks.The levels of serum brain-gut peptide indexes[P Substance and neurotensin（NT）]in both groups before and after treatment were observed,and the clinical efficacy as well as the reoccurrence rate in half a year′s followup were evaluated.Results After 8 weeks′treatment,the levels of serum SP and NT in both groups were increased obviously,with the observation group superior to the control group（P〈0.05）.Meanwhile,the total clinical efficiency in observation group was much higher than that in control group（χ^2= 4.04,P〈0.05）.Half-a-year follow-up showed that the reoccurrence rate in observation group was obviously lower than in control group（χ^2= 4.85,P〈0.05）.Conclusion Saccharomyces boulardii combined with Lactulose has reliable curative effect in children with FC and can reduce the reoccurrence rate,the mechanism of action of which may closely associated with its effects of raising the levels of serum SP and NT and promoting intestinal tract movement.

关 键 词：功能性便秘 儿童 布拉酵母 乳果糖口服液 脑肠肽 

分 类 号：R723.11[医药卫生—儿科]