Strontium Substituted Nanohydroxyapatite Incorporated 3D Printing Scaffold for Bone Tissue Engineering  

作　　者：LIU Dinghua NIL Wei CHEN Liang WANG Weizhong TAO Ling DU Haibo HE Chuanglong 刘顶华;聂伟;陈良;王伟忠;陶玲;杜海波;何创龙(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University)

机构地区：College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

出　　处：《Journal of Donghua University(English Edition)》2018年第1期18-23,共6页东华大学学报（英文版）

基　　金：National Natural Science Foundations of China(Nos.31771048,31570984,31271028);International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality,China(No.15540723400);Innovation Foundation of Donghua University,China(No.EG2017012);Biomedical Textile Materials Science and Technology(111 Project),China(No.B07024)

摘　　要：The customized implants which are composed of polycaprolactone( PCL) and strontium substituted nanohydroxyapatite( SrHA) were fabricated successfully by using fused deposition modeling( FDM),which is a simple 3 D printing technology for fabricating personalized products. The physical and chemical properties of composite scaffolds were characterized by transmission electron microscopy( TEM), Fourier transform infrared spectroscopy( FTIR), X-Ray diffraction( XRD) and inductively coupled plasma-atomic emission spectroscopy( ICPAES). The results suggested that strontium element was successfully doped into nanohydroxyapatite and all scaffolds showed the homogeneous network structure. Furthermore, the in vitro biocompatibility of the scaffolds was evaluated by cell counting kit-8( CCK-8) assay. The data indicated that the prepared scaffolds exhibited excellent biocompatibility to bone marrow mesenchymal stem cells( BMSCs). Besides,strontium element can be released from PCL-SrHA scaffolds in a sustained manner. Therefore,the 3 D printing PCL-SrHA scaffolds hold great potential for bone tissue engineering.The customized implants which are composed of polycaprolactone（ PCL） and strontium substituted nanohydroxyapatite（ SrHA） were fabricated successfully by using fused deposition modeling（ FDM）,which is a simple 3 D printing technology for fabricating personalized products. The physical and chemical properties of composite scaffolds were characterized by transmission electron microscopy（ TEM）, Fourier transform infrared spectroscopy（ FTIR）, X-Ray diffraction（ XRD） and inductively coupled plasma-atomic emission spectroscopy（ ICPAES）. The results suggested that strontium element was successfully doped into nanohydroxyapatite and all scaffolds showed the homogeneous network structure. Furthermore, the in vitro biocompatibility of the scaffolds was evaluated by cell counting kit-8（ CCK-8） assay. The data indicated that the prepared scaffolds exhibited excellent biocompatibility to bone marrow mesenchymal stem cells（ BMSCs）. Besides,strontium element can be released from PCL-SrHA scaffolds in a sustained manner. Therefore,the 3 D printing PCL-SrHA scaffolds hold great potential for bone tissue engineering.

关 键 词：3D printing strontium hydroxyapatite polycaprolactone(PCL) bone tissue engineering 

分 类 号：P318.08[天文地球—固体地球物理学]