牙髓干细胞对中枢神经系统疾病的治疗新进展  

New progress in the treatment of central nervous system diseases with dental pulp stem cells

作　　者：袁忠治 胡伟平[1] YUAN Zhongzhi, HU Weiping.(Department of Prosthodontics, the Second Hospital Affiliated to Harbin Medical University, Harbin 150086, Chin)

机构地区：[1]哈尔滨医科大学附属第二医院口腔修复科,黑龙江哈尔滨150086

出　　处：《口腔医学》2018年第5期471-475,共5页Stomatology

基　　金：黑龙江省自然科学基金(H2013101)

摘　　要：牙髓干细胞(dental pulp stem cells,DPSC)是神经嵴来源的外胚间充质干细胞,具有强大的自我更新和多向分化能力,可以用相对容易的方法从拔除的牙齿牙髓中分离出来。越来越多的证据表明,牙髓干细胞疗法在中枢神经系统(central nervous system,CNS)疾病和视网膜损伤疾病的治疗中有很大的潜力。牙髓干细胞可以通过多个途径产生疗效,特别是旁分泌介导分泌的一系列营养因子,被视为其发挥作用的主导机制。本文就牙髓干细胞修复中枢神经系统损伤的最新证据展开综述,包括其对视网膜神经节细胞的神经保护作用及在视神经损伤的再生与青光眼的治疗中的作用。Dental pulp stem cells（ DPSC） are mesenchymal stem cells derived from neural crest,which have strong self-renewal and multidifferentiation ability. They can be removed from the tooth pulp of the extracted tooth in a relatively easy way. Accumulating evidence suggested that dental pulp stem cell therapy has a great potential in the treatment of diseases of the central nervous system（ CNS） and retinal damage. Dental pulp stem cells can produce therapeutic effects in a number of ways,especially a series of trophic factors mediated by paracrine secretion,which is seen as the dominant mechanism for its function. In this paper,the latest evidence about the repair of central nervous system injury by dental pulp stem cells,including neuroprotective effects on retinal ganglion cells and the role in optic nerve regeneration and the treatment of glaucoma,is reviewed.

关 键 词：牙髓干细胞 中枢神经系统 视神经 

分 类 号：R318[医药卫生—生物医学工程]