银杏叶片联合索他洛尔治疗心律失常患者疗效及对心功能、心室肌稳定性和血CRP、VIP、AngⅡ水平的影响  

Curative Effect of Ginkgo Biloba Tablets Combined with Sotalol in the Treatment of Arrhythmia and the Influence on Cardiac Function,Ventricular Muscle Stability and Blood CRP,VIP and Ang Ⅱ levels

作　　者：侯亚敏[1] 孙成磊 程国良 刘新灵 李新华[1] Hou Yamin;Sun Chenglei;Cheng Guoliang;Liu Xinling;Li Xinhua(Department of Cardiology,Linyi people’s Hospita;National Chiral Pharmaceutical Engineering Technology Research Cente)

机构地区：[1]临沂市人民医院心内科,临沂276003 [2]国家手性制药工程技术研究中心,临沂276000

出　　处：《中华心脏与心律电子杂志》2017年第3期156-160,共5页Chinese Journal of Heart and Heart Rhythm(Electronic Edition)

摘　　要：目的探究银杏叶片联合索他洛尔治疗心律失常患者疗效及对心功能、心室肌稳定性和血C反应蛋白(CRP)、血管活性肠肽(VIP)、血管紧张素Ⅱ(AngⅡ)水平的影响。方法选取2016年6月至2017年6月临沂市人民医院收治的心律失常患者124例为受试对象,按照随机数表分为联合组与对照组各62例。对照组患者仅予以索他洛尔治疗,联合组患者则在其基础上联合银杏叶片进行治疗。比较治疗前及治疗1个月后,两组患心功能[左室射血分数(LVEF)、每搏心输出量(SV)]、心室肌稳定性[T波峰末间期(Tpe)、校正QT离散度(QTcd)]、炎性反应因子[CRP、单核细胞趋化蛋白-1(MCP-1)]、神经信使分子[VIP、一氧化氮(NO)]、高血压标志物[AngⅡ、醛固酮(ALD)]水平变化,分析治疗1个月后,两组患者治疗效果及药物不良反应发生情况差异。结果治疗1个月后,两组患者LVEF、SV、VIP、NO水平均较治疗前有显著提升,且联合组明显高于同期对照组(P均<0.05);两组患者Tpe、QTcd、CRP、MCP-1、AngⅡ、ALD水平均较治疗前有显著下降,且联合组明显低于同期对照组(P均<0.05);联合组患者治疗有效率明显高于对照组(P<0.05)。治疗1个月内,两组患者各项药物不良反应发生率比较,差异均无统计学意义(P均>0.05)。结论银杏叶片联合索他洛尔可明显优化心律失常患者心功能及心室肌稳定性,对血浆CRP、VIP、AngⅡ水平均有较强的改善作用。Objective To explore the curative effect of Ginkgo biloba tablets combined with sotalol in the treatment of arrhythmia and the influence on cardiac function,ventricular muscle stability,blood C reactive protein（ CRP）,vasoactive intestinal peptide（ VIP） and angiotensin Ⅱ（ Ang Ⅱ） levels. Methods One hundred and twenty four patients with arrhythmia treated in our hospital were selected as subjects,and they were divided into the combined group and the control group with 62 cases in each group by the random number table method. The control group were treated with sotalol alone,while the combined group were treated with Ginkgo biloba tablets combined with sotalol. Changes in cardiac function [left ventricular ejection fraction（ LVEF）,stroke volume（ SV） ],ventricular muscle stability [T peak end interval（ Tpe）,corrected QT dispersion（ QTcd） ],inflammatory factors [CRP,monocyte chemoattractant protein-1（ MCP-1） ],nerve messenger molecules [VIP,nitric oxide（ NO） ] and hypertension markers [Ang Ⅱ,aldosterone（ ALD） ]before the treatment and after 1 month of treatment were compared between the two groups. The therapeutic effects in two groups after 1 month of treatment and the incidence of adverse drug reactions within 1 month were analyzed. Results After 1 month of treatment,the LVEF,SV,VIP and NO level in the two groups were significantly increased,showing the combined group 〉 the control group（ all P 〈 0. 05）,while the Tpe,QTcd,CRP,MCP-1,Ang Ⅱ and ALD levels were significantly decreased,showing the combined group 〈 the control group（ all P 〈 0. 05）. The response rate of the combined group was significantly higher than that of the control group（ P 〈 0. 05）. After 1 month of treatment,there was no significant difference in the incidence of adverse drug reactions between the two groups（ P 〉 0. 05）. Conclusion Ginkgo biloba tablets combined with sotalol can obviously improve the cardiac function and ventricular muscle stability in patients with arrhyt

关 键 词：银杏叶片 索他洛尔 心律失常 心功能 心室肌稳定性 

分 类 号：R541.7[医药卫生—心血管疾病]