5-氨基酮戊酸光动力疗法联合甘露聚糖肽胶囊治疗难治性颜面部扁平疣疗效观察  

Clinical Observation of 5-Aminolevulinic Acid Photodynamic Therapy Combined with Mannatide Capsule on the Treatment of Facial Verruca Plana

作　　者：吴波[1] 程燕[1] 刘雪莹[1] WU Bo;CHENG Yan;LIU Xueying(Department of Dermatology, the Second People＇s Hospital of Chengdu, Chengdu Institute of Dermatology and STD Treatment and Control, Sichuan Chengdu 610017, China)

机构地区：[1]成都市第二人民医院皮肤科成都市皮肤病性病防治研究所,四川成都610017

出　　处：《中国医药导刊》2018年第2期84-86,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:观察5-氨基酮戊酸(ALA)光动力疗法联合甘露聚糖肽胶囊治疗难治性颜面部扁平疣的临床疗效及安全性。方法:将150例患者随机分为光动力对照组、甘露聚糖肽胶囊对照组、光动力联合甘露聚糖肽胶囊组(联合组),分别观察各组的疗效。结果:光动力对照组、甘露聚糖肽胶囊对照组、联合组的有效率依次分别为64.0%、56.0%和86.0%,联合组疗效明显优于光动力对照组和甘露聚糖肽胶囊对照组,差异有统计学意义(P<0.05)。3组痊愈患者均随访3个月,复发率分别为25.0%、33.3%、15.8%,联合组复发率低于光动力组和甘露聚糖肽组(P<0.05)。3组患者中仅光动力组、联合组分别有4例和2例患者在光动力治疗后面部皮肤出现轻度红肿、灼痛感、瘙痒感,生理盐水冷湿敷处理后上述症状缓解,未见其他明显不良反应。结论:ALA光动力疗法联合甘露聚糖肽胶囊治疗难治性颜面部扁平疣能提高临床治愈率,降低复发率,临床疗效确切,安全易操作。Objective： To observe the efficacy and safety of 5-aminolevulinic acid photodynamic therapy（ALA-PDT） combined with mannatide capsule on the treatment of facial verruca plana. Methods： 150 patients were randomly divided into the ALA-PDT group,the mannatide capsule group and the ALA-PDT ＋ mannatide capsule group,the efficacy of each group was observed respectively. Results：The effective rates of the ALA-PDT group,the mannatide capsule group and the ALA-PDT ＋ mannatide capsule group were 64. 0%,56. 0% and 86. 0%,and the ALA-PDT ＋ mannatide capsule group had better effective rate than the other two groups（P〈0. 05）. After 3 months follow-ups,the recurrence rates of the ALA-PDT group,the mannatide capsule group and the ALA-PDT ＋ mannatide capsule group were 25. 0%,33. 3% and 15. 8%. The recurrence rate of the ALA-PDT ＋ mannatide capsule group was lower than that of the other two groups（P〈0. 05）. Mild facial redness,burning and itching occurred in 6 patients after ALA-PDT and relieved by hydropathic compress with normal saline. None serious adverse reactions were observed. Conclusion： The ALA-PDT combined with mannatide capsule can improve the clinical healing rate and lower the recurrence rate of facial verruca plana. This therapeutic method is safe and effective.

关 键 词：5-氨基酮戊酸(ALA) 光动力疗法 甘露聚糖肽 扁平疣 

分 类 号：R751.05[医药卫生—皮肤病学与性病学] R752.52[医药卫生—临床医学]