广州地区热带无爪螨在呼吸道过敏性疾病的致敏模式  

The sensitization pattern of Blomia tropicalis in allergic respiratory disease in Guangzhou

作　　者：刘晓清[1] 郑佩燕[1] 蔡传旭 韦妮莉[1] 黄志锋 邹湘玮 孙宝清[1] LIU Xiaoqing;ZHENG Peiyan;CAI Chuanxu;WEI Nili;HUANG Zhifeng;ZOU Xiangwei;SUN Baoqing(Department of Allergy Clinical Immunology Guangzhou Institute of Respiratory Health State Key Laboratory of Respiratory Disease,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院呼吸疾病国家重点实验室广州呼吸健康研究院变态反应科,广州510120

出　　处：《实用医学杂志》2018年第10期1720-1724,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81572063;81601394);广州市医药卫生科技基金资助项目(编号:2017A013010017)

摘　　要：目的探讨热带无爪螨在呼吸道过敏性疾病中的致敏模式,及其与过敏性鼻炎和(或)哮喘的联系。方法筛选广州地区尘螨致敏过敏性鼻炎和(或)哮喘患者330例,对其血清热带无爪螨、屋尘螨和粉尘螨的sIgE检测结果进行分析。结果热带无爪螨的致敏率均明显低于屋尘螨和粉尘螨(均P<0.001)。3种螨同时致敏者占80.0%,仅0.3%患者只对热带无爪螨致敏。3种螨的sIgE水平两两间均具有显著正相关性(P<0.001),屋尘螨与粉尘螨致敏高度相关(rs=0.906),热带无爪螨与屋尘螨、粉尘螨的致敏呈中度相关(rs=0.540和rs=0.512)。随着热带无爪螨sIgE水平的升高,合并屋尘螨或粉尘螨重度致敏(sIgE水平为5~6级)的阳性率均显著升高(P<0.001)。过敏性鼻炎伴哮喘患者的屋尘螨、粉尘螨sIgE显著高于单纯鼻炎、哮喘患者(均P<0.001),过敏性鼻炎伴哮喘和哮喘患者中,热带无爪螨sIgE水平显著高于鼻炎患者(P=0.006和P=0.020)。结论热带无爪螨致敏患者常合并屋尘螨和粉尘螨同时致敏,且哮喘患者热带无爪螨致敏程度更高。Objective To investigate the sensitization pattern of Blomia tropicalis in patients with aller-gic respiratory disease and the association between Blomia tropicalis with allergic rhinitis and/or asthma. Methods 330 allergic rhinitis and/or asthma patients sensitized with mites were selected in Guangzhou,and s Ig E lev-el in the serum of all recruited patients of Blomia tropical,Dermatophagoide pteronyssinus and Dermatophagoide fa-rina was measured. Results The sensitization rate of Blomia tropicalis was significantly lower than that of Derma-tophagoide pteronyssinus and Dermatophagoide farina（P〈0.001,both）. 80.0% Patients were sensitized with boththree mites,and only 0.3% patients were of monosensitization to Blomia tropicalis. The s Ig E of these three miteswere significantly positive correlated with each other（P〈0.001）,Dermatophagoide pteronyssinus and Derma-tophagoide farina have strong correlation（r=0.906）,Blomia tropicalis has moderate correlation with Dermatopha-goide pteronyssinus and Dermatophagoide farina（r = 0.540 and r=0.512,respectively）. With the increase ofBlomia tropicalis s Ig E,the severe sensitization rate（s Ig E level：class 5~6）of patients sensitized combined Der-matophagoide pteronyssinus or Dermatophagoide farina significantly increased（P〈0.001）. The s Ig E level of Der-matophagoide pteronyssinus and Dermatophagoide farina in allergic asthma and rhinitis patients were significantlyhigher than that of patients with rhinitis or asthma alone（P〈0.001）,and the s Ig E level of Blomia tropicalis in pa-tients with both allergic asthma and rhinitis or with asthma alone were also significantly higher than that of patientswith rhinitis alone（P=0.006 and P=0.020,respectively）. Conclusion The Blomia tropicalis sensitized pa-tients usually sensitize together with Dermatophagoide pteronyssinus or Dermatophagoide farina,and the degree ofBlomia tropicalis sensitized in asthma patients are higher.

关 键 词：热带无爪螨 屋尘螨 粉尘螨 鼻炎 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]