山东地区0～12岁儿童人巨细胞病毒抗体阳性特征分析  

Analysis of positive features of cytomegalovirus antibody in children aged 0-12 years in Shandong

作　　者：马婷婷 刘义庆[1] 路超[1] 褚福禄[1] 刘占锋 刘志[1] 贾伟[1] MA Tingting;LIU Yiqing;LU Chao;CHU Fulu;LIU Zhanfeng;LIU Zhi;JIA Wei(Department of Clinical Laboratory ,Shandong Provincial Hospital Affiliated to Shandong University , Ji ＇nan , Shandong 250021 , China)

机构地区：[1]山东大学附属省立医院临床医学检验部,山东济南250021

出　　处：《国际检验医学杂志》2018年第10期1188-1190,共3页International Journal of Laboratory Medicine

基　　金：山东省自然科学基金资助项目(ZR2016HM52);山东省临床重点专科建设项目(鲁卫医字[2013]26号);山东省医药卫生重点实验室项目(鲁卫科教国合字[2013]49号)

摘　　要：目的分析山东地区0~12岁儿童人巨细胞病毒抗体的阳性特征。方法收集2014年1月至2016年12月在山东大学附属省立医院门诊就诊和住院的儿童患者1 429例。用化学发光方法检测血清人巨细胞病毒IgG和IgM抗体。用SPSS21.0软件进行统计分析。结果巨细胞病毒IgG抗体和IgM抗体阳性率分别为89.36%和16.59%,男性巨细胞病毒IgG抗体阳性率为88.04%,明显低于女性的91.32%(P<0.05)。男性巨细胞病毒IgM抗体阳性率为14.07%,明显低于女性的20.31%(P<0.05)。巨细胞病毒IgG抗体阳性率以6~12个月年龄组最低(73.68%),0~<6个月年龄组最高(92.73%);巨细胞病毒IgM抗体阳性率以4~12岁年龄组最低(10.26%),1~3岁年龄组最高(21.57%)。巨细胞病毒IgM抗体阳性率冬季最高为22.92%,秋季阳性率最低为11.11%,四个季节之间阳性率差异有统计学意义(P<0.05)。共检出4种巨细胞病毒抗体项目组合模式,以巨细胞病毒IgG抗体阳性、巨细胞病毒IgM抗体双阴性模式最多见,占73.27%。结论山东地区0~12岁儿童人巨细胞病毒抗体的阳性率存在性别、年龄和季节差异,应加强对儿童人巨细胞病毒感染的防控。Objective To analyze the positive features of cytomegalovirus antibodies in children aged 0-12 years in Shandong.Methods 1 429 inpatients and outpatiens who came to Shandong Provincial Hospital Affiliated to Shandong University from January 2014 to December 2016 were enrolled in the study.Cytomegalovirus IgG and IgM antibodies were detected by chemiluminescence.SPSS21.0 software was used for statistical analysis.Results The positive rate of IgG and IgM antibody of cytomegalovirus was 89.36% and 16.59% respectively,and the positive rate of IgG antibody of cytomegalovirus in male was 88.04%,which was significantly lower than 91.32%in female（P0.05）.The positive rate of cytomegalovirus IgM antibody in male was 14.07%,which was significantly lower than 20.31%in female（P0.05）.The positive rate of IgG antibody of cytomegalovirus was the lowest in 6-12 months age group（73.68%）,the highest in 0-6 months age group（92.73%）;cytomegalovirus IgM antibody positive rate was the lowest in 4-12 year-old age group（10.26%）,and the highest in 1-3 year-old age group（21.57%）.The positive rate of IgM antibody of cytomegalovirus was the highest in winter（22.92%）and the lowest in autumn（11.11%）,and the differences of positive rate between the four seasons were statistically significant（P0.05）.A total of 4 cytomegalovirus antibody combination patterns were detected,with the most common type of cytomegalovirus IgG antibody positive and cytomegalovirus IgM antibody double negative,accounting for 73.27%.Conclusion There were differences in sex,age and season in the positive rates of CMV antibody in Shandong area.Prevention and control of cytomegalovirus infection in children should be strengthened.

关 键 词：人巨细胞病毒 抗体 儿童 山东 

分 类 号：R181.3[医药卫生—流行病学]