血管内介入方法制备非人灵长类动物局部脑缺血模型的研究进展  

Research progress of focal ischemic stroke in nonhuman primates using endovascular methods

作　　者：吴迪[1] 何小夺 陈健[1] 丁玉川[1] WU Di;HE Xiaoduo;CHEN Jian;DING Yuchuan(China？America Institute of Neuroscience,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院中美神经科学研究所,北京100053

出　　处：《中国比较医学杂志》2018年第5期16-20,共5页Chinese Journal of Comparative Medicine

基　　金：北京市医管局青苗项目(编号:QML20170802)

摘　　要：由于多项转化研究的失败,卒中治疗专业委员会建议,应该在非人灵长类动物局部脑缺血模型上进行临床前研究。采用血管内介入方法制备局部脑缺血模型与人类卒中发病过程一致,而且还可以进行血管内介入治疗,因此是模拟缺血性脑卒中发病与治疗过程的最佳动物模型。目前研究采用多种血管内介入方法制备模型,结果也不一致,本文将对血管内介入方法制备的非人灵长类动物进行总结,对各种模型的优缺点和潜在应用进行分析。此外,本文还根据不同类型的栓子,不同的闭塞部位,异常的血流动力学和可能的应用范围进行进一步的分析。选择合适的非人灵长类动物模型将有助于推动转化研究开展。The Stroke Therapy Academic Industry Roundtable（STAIR） committee has suggested that nonhuman primates（NHPs） should be used for preclinical stroke studies owing to previous translational failures. Ischemia induced by endovascular method closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This method also shows potential for endovascular treatment. This review provides a detailed summary of NHP models using endovascular method,including advantages and disadvantages,and potential applications. Additionally,we also provide further analysis based on different kinds of emboli,infract size,and abnormal hemodynamics. Selection of the optimum model will pave the way for translational research.

关 键 词：卒中 动物模型 非人灵长类动物 

分 类 号：R33[医药卫生—人体生理学]