氢氯噻嗪联合厄贝沙坦片治疗轻中度高血压68例疗效观察  

Observations on the efficacy of hydrochlorothiazide combined with irbesartan cilexetil in treating 68 mild to moderate hypertension cases

作　　者：赵锦[1] Zhao Jin(Department of Internal Mean District, Shenzhen,Guangdong Province 518101,China)

机构地区：[1]广东省深圳市宝安区人民医院内科,518101

出　　处：《中华心脏与心律电子杂志》2016年第1期43-45,共3页Chinese Journal of Heart and Heart Rhythm(Electronic Edition)

摘　　要：目的探讨氢氯噻嗪联合厄贝沙坦片治疗轻中度高血压的临床疗效。方法选择2014年3月至2016年2月已确诊的轻中度原发性高血压患者136例,将其按就诊先后顺序随机分为观察组和对照组各68例。对照组予以口服厄贝沙坦片>5 mg,1次/d;观察组在对照组口服厄贝沙坦片治疗基础上加服氢氯噻嗪片12.5 mg,1次/d。两组患者均为晨起口服,疗程均为2个月。结果观察组总有效率82.35%,对照组总有效率66.18%,两组比较差异有统计学意义(P<0.05);观察组和对照组治疗后的收缩压和舒张压均较治疗前显著降低(P<0.01),且观察组治疗后的收缩压和舒张压与对照组比较显著降低,两组比较差异有统计学意义(P<0.05);两组心率变化治疗前后比较差异无统计学意义(P<0.05),而尿酸及血钾治疗前后两项指标变化比较差异无统计学意义(P<0.05)。结论厄贝沙坦片、氢氯噻嗪和二者联合均能有效控制血压,但联合用药对轻中度高血压患者降压效果更显著,且耐受性和安全性好。Objective Investigate the clinical efficacy of hydrochlorothiazide combined with irbesartancilexetil in treating mild to moderate hypertensive cases. Methods 136 mild to moderate cases of essential hypertension diagnosed between March 2014 and February 2016,were randomly divided into an observation group and a control group according to their order of out-patient registration,each containing 68 cases. Irbesartancilexetil（ 4 mg qdpo） was given to the control group; while the same medication together with hydrochlorothiazide（ 12. 5 mg qdpo） was administered to the observation group. Medications of the two groups were all taken orally in the morning as soon as subjects woke up,and with the same treating period of2 months. Results The total effective ratio of the medication was 82. 35% for the observation group,and66. 18% for the control group,the difference between the two groups had statistical significance（ P 〈0. 05）. SBP and DBP of the two groups were all remarkably reduced in comparison to their former levels before treatments（ P 〈 0. 01）; SBP and DBP reductions of the observation group were more prominent compared with the control group,which difference also indicated statistical significance（ P 〈 0. 05）. Heart rate variations before and aft treatments of the two groups had no significant difference（ P 〈 0. 05）,both groups without hyperuricemia or hyponatremia,BUA（ blood uric acid） and serum sodium variations between the two groups had no significant difference as well（ P 〈 0. 05）. Conclusion Irbesartancilexetil,hydrochlorothiazide and their combined medication all exerted effective control over blood pressure,but combined medication had more superior efficacy in reducing blood pressures of mild-moderate hypertensive patients,with improved tolerance and safety.

关 键 词：原发性高血压 厄贝沙坦片/血管紧张素Ⅱ受体拮抗剂 氢氯噻嗪/利尿剂 效果 

分 类 号：R544.1[医药卫生—心血管疾病]