探讨免疫性复发性流产患者孕前及孕早期血液流变学的特点及变化情况  

Investigation on characteristics and changes of hemorrheology in patients with immune recurrent spontaneous abortion before and during early pregnancy

作　　者：张丹[1] 林琳[1] 王晓彩[1] 冯小静[1] 张丽君[1] ZHANG Dan, LIN Lin, WANG Xiao-cai, et al. （Department of Obstetrics, Shenyang Maternity and Infant Hospital, Shenyang 110011, China）

机构地区：[1]沈阳市妇婴医院产科,110011

出　　处：《中国现代药物应用》2018年第10期21-23,共3页Chinese Journal of Modern Drug Application

基　　金：沈阳市卫生局科研课题(项目编号:2016)

摘　　要：目的探讨免疫性复发性流产(RSA)患者孕前及孕早期血液流变学的特点及变化情况。方法选取免疫性RSA患者34例作为RSA组,另选取同期正常产检孕妇30例作为对照组。检测两组孕前及孕早期血液流变学指标,比较两组孕前及孕早期血液流变学指标。结果 RSA组患者孕早期全血粘度切变率[1S-1(19.52±1.23)m Pa·s、5S-1(8.76±0.42)m Pa·s、30S-1(5.09±0.25)m Pa·s、200S-1(3.89±0.22)m Pa·s]及全血高、低切还原粘度(5.48±0.39)、(40.11±3.47)m Pa·s均高于孕前的(18.70±1.76)、(8.20±0.65)、(4.84±0.34)、(3.71±0.25)、(5.20±0.56)、(37.91±2.94)m Pa·s,差异均有统计学意义(P<0.05);孕前与孕早期血浆粘度比较差异无统计学意义(P>0.05)。对照组患者孕早期全血粘度切变率(1S-1、5S-1、30S-1、200S-1)和全血高、低切还原粘度及血浆粘度与孕前比较差异均无统计学意义(P>0.05)。RSA组患者孕前全血粘度切变率(1S-1、5S-1、30S-1、200S-1)、全血低切还原粘度均高于对照组,差异有统计学意义(P<0.05);两组孕前全血高切还原粘度及血浆粘度比较差异无统计学意义(P>0.05)。RSA组患者孕早期全血粘度切变率(1S-1、5S-1、30S-1、200S-1)及全血高、低切还原粘度均高于对照组,差异均有统计学意义(P<0.05);两组孕早期血浆粘度比较差异无统计学意义(P>0.05)。结论免疫性RSA患者孕前及孕早期血液流变学明显异常,孕前及孕早期给予积极抗凝等针对性治疗,可有利于降低流产率及改善妊娠结局。Objective To discuss the characteristics and changes of hemorrheology in patients with immune recurrent spontaneous abortion（RSA） before and during early pregnancy. Methods There were 34 immune RSA patients as RSA group, and another concurrent 30 normal pregnant women as control group. The hemorheological indexes of the two groups were detected before and during early pregnancy, and the hemorheological index of the two groups were compared before and during early pregnancy. Results RSA group had higher early pregnancy whole blood viscosity shear rate [1 S-1（19.52±1.23） m Pa·s, 5 S-1（8.76±0.42） m Pa·s, 30 S-1（5.09±0.25） m Pa·s and 200 S-1（3.89±0.22） m Pa·s] and high and low reduction viscosity of whole blood as（5.48±0.39） and（40.11±3.47） m Pa·s than（18.70±1.76）,（8.20±0.65）,（4.84±0.34）,（3.71±0.25）,（5.20±0.56） and（37.91±2.94） m Pa·s before pregnancy, and their difference was statistically significant（P〈0.05）. There was no statistically significant difference in plasma viscosity before and during early pregnancy（P〈0.05）. The control group had no statistically significant difference in early pregnancy whole blood viscosity shear rate（1 S-1, 5 S-1, 30 S-1 and 200 S-1） and high and low reduction viscosity of whole blood and plasma viscosity, comparing with before pregnancy（P〈0.05）. RSA group had higher early pregnancy whole blood viscosity shear rate（1 S-1, 5 S-1, 30 S-1 and 200 S-1） and low reduction viscosity of whole blood than the control group, and the difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in early pregnancy whole blood viscosity shear rate and plasma viscosity（P〈0.05）. RSA group had higher early pregnancy whole blood viscosity shear rate（1 S-1, 5 S-1, 30 S-1 and 200 S-1） and high and low reduction viscosity of whole blood than the control group, and their difference was statistically significant（P〈0.05）. Both groups had no statisti

关 键 词：复发性流产 血液流变学 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]