盐酸椒苯酮胺对新西兰兔心电图QT间期的影响  

Effects of Piperphentonamine Hydrochloride on QT Intervals of ECG in New Zealand Rabbits

作　　者：江丽[1,2] 欧思琳 吴云 赵月[2] 陈灶妹[2] 陈柯君[2] 吴庆荣 朱晋辉 李茹冰[1,2] JIANG Li;OU Si-lin;WU Yun;ZHAO Yue;CHEN Zao- mei;CHEN Ke- jun;WU Qing -rong;ZHU Jin -hui;LI Ru- bing(Southern Meclical University, Guangzhou, Guangdong, 520515, China;Guangzhou General Hospital of Guangzhou Military Cormmand ,Guangzhou ,Guangdong ,510010,China)

机构地区：[1]南方医科大学,广东广州510515 [2]广州军区广州总医院,广东广州510010

出　　处：《动物医学进展》2018年第5期73-77,共5页Progress In Veterinary Medicine

基　　金：军队后勤科研项目(CGZ16C009);广州市科技计划项目(201509010012);广州市科技计划项目(201704020173)

摘　　要：旨在观察不同剂量盐酸椒苯酮胺(piperphentonamine hydrochloride,PPTA)对新西兰兔心电图QT间期(从QRS波开始到T波结束时的时限)的影响。将40只新西兰兔随机分为5组,每组8只,分别为溶剂对照组(5%葡萄糖)、PPTA低(2.5mg/kg)、中(10mg/kg)、高(25mg/kg)剂量组以及阳性对照组(9mg/kg索他洛尔),采用体表心电图技术,通过Pclab-530C生物医学信号采集处理系统记录各组新西兰兔注射相应药物后PPTA标准肢体Ⅱ导联心电图变化。结果表明,2.5mg/kg、10mg/kg PPTA在缓慢给药后不引发QT间期延长,25mg/kg PPTA在缓慢给药后15min内引起QT间期轻度延长(P<0.05);PPTA对QT间期的影响主要发生在给药后0~15min,45min后基本恢复正常。因此,低、中剂量盐酸椒苯酮胺(PPTA)不引发新西兰兔心电图QT间期延长,安全性较高,高剂量可能有引发QT间期延长风险,提示在临床用药时需要注意药物使用剂量,以防QT间期延长和心律失常的发生。This study aimed to observe the effects of different doses of piperphentonamine hydrochloride（PPTA）on QT intervals in New Zealand rabbits.Forty New Zealand rabbits were randomly divided into 5 groups（n=8）：solvent control group（5% glucose）,low-（2.5 mg/kg）,medium-（10 mg/kg）,high-dosage PPTA groups（25 mg/kg）and positive control group（9 mg/kg sotalol）.The surface ECG technique was used to record the ECG change of rabbits in the lead II dent way after giving corresponding drugs by Pclab-530 Cbiomedical signal acquisition and processing system.Result showed that 2.5 mg/kg and 10 mg/kg PPTA did not cause QT interval prolongation after administration,25 mg/kg PPTA led to QT interval prolongation slightly within 15 min after injection（P〈0.05）;The influence of PPTA on QT interval mainly happened after drug injection from 0 min to 15 min,45 min later,QT interval returned to normal.Therefore,low-dosage and medium-dosage of PPTA do not cause QT interval prolongation in New Zealand rabbits,with high security,high-dosage of PPTA has a potential risk of arrhythmia,and suggest that when we use the drug in clinic,we should pay more attention to the dose of it to prevent the QT prolongation and arrhythmia.

关 键 词：盐酸椒苯酮胺(PPTA) 新西兰兔 QT间期延长 心电图研究 心律失常 

分 类 号：S859[农业科学—临床兽医学] S854.42[农业科学—兽医学]