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作 者:王心强 郭艳华 宫念樵[1] 卢峡 朱兰 徐晶 昌盛 杜敦峰 刘斌[1] 蒋继贫 陈刚[1] 林正斌 曾凡军[1] 张伟杰[1] 周平 陈知水[1] 明长生[1] WANG Xinqiang, GUO Yanhua , GONG Nianqiao , et al.(Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology, Wuhan 430030, Chin)
机构地区:[1]华中科技大学同济医学院附属同济医院器官移植研究所教育部/卫生部器官移植重点实验室,武汉430030
出 处:《临床外科杂志》2018年第4期292-296,共5页Journal of Clinical Surgery
基 金:国家高技术研究发展计划(863计划)资助项目(2012AA021010)
摘 要:目的分析扩展标准的公民逝世后器官捐献(ECD)肾移植病人的近期效果。方法ECD肾移植50例,标准的公民逝世后器官捐献(SCD)肾移植140例,比较两组移植肾病人早期恢复情况、术后1年内移植肾功能变化、受者和移植肾存活情况以及排斥反应、感染和手术并发症发生率。结果 ECD肾移植组病人术后1年的受者和移植肾存活率、总体感染发生率、急性排斥反应发生率与同期SCD组病人比较,差异均无统计学意义(P>0.05)。但ECD组病人在肾移植术后第1、3、6、12个月血肌酐水平高于SCD组,ECD组肾小球滤过率(eGFR)SCD组,差异有统计学意义(P<0.05)。结论现行ECD纳入标准下ECD肾移植术后近期效果良好,虽然在移植肾功能(血肌酐水平和eGFR)方面差于SCD肾移植,但在合理选择受者的前提下ECD可作为扩大供体来源的重要途径,其远期效果仍需进步观察。Objective To analyze the outcomes of renal transplantation that donation from expanded criteria donors( ECD) in our single center. Methods Reported 50 cases of ECD renal transplantation and 140 cases of standard criteria donors( SCD) renal transplantation in the same period. We compared the early graft recovery( the percentage of patients in IGF,SGF,DGF) and one year survival rate after transplantation in both two group. Results The differences between ECD group and SCD group in 1-year survival rate of recipients and graft were not statistically significant( P〉 0. 05). But the ECD group in1,3,6 and 12 mouth post-surgery the serum creatinine and e GFR was worse than the SCD group. The differences had statistically significant( P 〈 0. 05). Conclusion While ECD was worse than SCD in transplant renal function( serum creatinine level and e GFR). But there was no significant difference in the early stage of renal transplantation between ECD and SCD,and the reasonable use of ECD for kidney can be an important way to deal with the shortage of organs. But the long-term graft survival should be explored in further follow-up.
关 键 词:扩展标准的公民逝世后器官捐献 肾移植
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