座壳孢及其有性型(子囊菌门)代谢产物研究进展  

Research progress on metabolites from Aschersonia and its teleomorph(Ascomycota)

作　　者：付德来[1] 陈宇熹[2] 郭庆丰[1] 毛丽慧 费姣 邱君志[1] FU De-Lai;CHEN Yu-Xi;GUO Qing-Feng;MAO Li-Hui;FEI Jiao;QIU Jun-Zhi(College of Life Sciences, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China;College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China)

机构地区：[1]福建农林大学生命科学学院闽台作物有害生物生态防控国家重点实验室,福建福州350002 [2]福建农林大学植物保护学院,福建福州350002

出　　处：《菌物学报》2018年第5期541-554,共14页Mycosystema

基　　金：国家自然科学基金(31470156;31670026);福建省科技计划重点项目(2016I0003)~~

摘　　要：座壳孢及其有性型是一类重要的虫生真菌,隶属子囊菌门、粪菌纲、肉座菌目、麦角菌科,能寄生粉虱和蚧类昆虫,可开发成一种环境友好型的生物农药。座壳孢及其有性型属成员广泛分布于热带和亚热带地区,该类群物种、栖息环境和生态适应的多样性使它们的代谢产物化学结构及其生物活性彰显出多样性特点,结构和功能多样的真菌代谢产物已成为发现新药先导化合物的重要资源。虫生真菌因其独特的生活方式和多种生存环境形成了与众不同的适应寄主特性及代谢通路,明显提高获得新颖结构、显著活性的代谢产物的几率,目前已是药物重点研发的领域。在座壳孢及其有性型代谢产物研究中已报道了萜类、黄酮类、醌类、环肽和甾醇等多种化合物,并具有抗肿瘤、抗疟疾、抗菌和杀虫等多种生物活性,可在农业、工业和医药保健等方面应用。本文对近年座壳孢及其有性型代谢产物的化学成分和生物活性等方面的研究进展进行概述,为促进座壳孢及其有性型代谢产物的深入研究、开发利用和新药创制提供参考。Aschersonia and its teleomorph is one of important entomogenous fungi belonging to Clavicicipitaceae, Hypocreales, Sordariomycetes, Ascomycota. They can parasitize whiteflies and scale insects, and can be developed into an environmentally friendly biopesticide as well. Members of Aschersonia and its teleomorph are distributed widely in tropical and subtropical regions. The diversity of species, habitat, and ecological adaptation lead to the production of versatile metabolites with various chemical structures and biological activities, and they have become an important resource for discovering precursor of new drugs. Entomogenous fungi have developed unique characteristics of host adaptability and metabolic pathways, causing the chance increased to obtain new metabolites hopefully applied as therapeutic agents. Versatility metabolites including terpenoids,flavonoids, quinones, cyclic peptides and sterols had been isolated from Aschersonia and its teleomorph. These isolated constituents displayed multiple bioactivities such as antitumor, antimalarial, antimicrobial and insecticidal activities, which could be widely used in agriculture, industry and medical care. The important metabolites and their bioactivities from the fungi are summarized as reference data for development of new drugs.

关 键 词：虫生真菌 座壳孢 代谢产物 生物活性 

分 类 号：Q936[生物学—微生物学]