基于模型的银杏叶提取物冷冻干燥优化的研究  

Ginkgo extracts lyophilization process optimization based on model

作　　者：高兴 刘代春 康青 李雄 于颖 GAO Xing;LIU Dai-chun;KANG Qing;LI Xiong;YU Ying(School of Engineering,China Phalanaceutical University,Nanjing 210009,Jiangsu Province,China;Truking Technology Ltd,Changsha 410600,Hunan Province,China)

机构地区：[1]中国药科大学工学院,江苏南京210009 [2]楚天科技股份有限公司,湖南长沙410600

出　　处：《化学工程》2018年第5期28-32,共5页Chemical Engineering(China)

基　　金：江苏省中青年骨干及校长海外研究及培训项目的资助

摘　　要：为了对银杏叶提取物冷冻干燥工艺进行优化,文章进行了传热传质模型的建立及简化,测量了银杏叶提取物的干层传质阻力系数等,进行了工艺模拟,给出了温度在-40—-15℃,压力从2—40 Pa的范围,升华时间小于100 h的模拟结果,模拟结果显示:压力越低升华时间越短,温度越高升华时间越短。在温度较低时,压力的变化对升华时间影响较大,温度较高时,压力的变化对升华时间影响较小。据此模拟结果及冻干显微镜实验,确定了优化的工艺操作参数为P_C=8 Pa,制品的最高温度为32℃,并进行了冻干实验,实验获得冻干产品性能好。该方法可以为其他药品的冷冻干燥最优参数的确定及升华时间的预测提供借鉴。In order to optimize the Ginkgo extracts lyophilization technology, the heat and mass transfer mathematical model were established and simplified, and the dry layer resistance coefficient and heat transfer coefficient was also obtained through experiment. The lyophilization simulation was carried out at the shelf temperatre -40- - 15℃, chamber plessre 2-40 Pa and the sublimating dry time limits in 100 hours. The simulation results show that the lower the chamber pressre is, the shorter the sublimation drying time is, and the higher the shelf temperature is, the shorter the sublimation drying time is. Mreover, when the shelf temperatre is low, the change of chamber plessre affects the sublimating dry time significantly, but when the shelf temperatre is high, the change of chamber plessme affects the sublimating dry time less. Based on the lesults of simulation and the freeze-drying microscopy experiment, the optimum operation parameter were ensured as： chamber ptessure is 8 Pa, the shelf temperatre is -32℃. According to this parameter, the validity experiment is performled, and the product performance from experiment is good. The comparision lesults between experiments and simulation show that the simplified mathematical model is correct to simulate the lyophilization process to forecast the Ginkgo extracts sublimating drying time and give the optimum technology parameter. The simplified mathematical model can be applied in the other drug lyophilization process.

关 键 词：银杏叶提取物 冷冻干燥 传热传质模型 过程模拟 工艺参数优化 

分 类 号：TB69[一般工业技术—制冷工程] TB79