Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel  

作　　者：Tao Li Xuehui Fan Yiyan Yu Linlin Chen Wenjun Huang Yan Yang Jimin Cao Xiaorong Zeng Xiaoqiu Tan 

机构地区：[1]Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Southwest Medical University

出　　处：《Science China(Life Sciences)》2018年第5期599-603,共5页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (30870903 to Xiaorong Zeng, 31300948,81670130 to Xiaoqiu Tan, 81670313 to Jimin Cao);Science and Technology Support Program of Sichuan Province (2011FZ0106 to Xiaorong Zeng)

摘　　要：Dear Editor,Small conductance Ca2＋-activated potassium （SK） channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2＋ levels and membrane potential （Adelman et al., 2012）. Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes （Xu et al., 2003）. This suggests that the SKDear Editor,Small conductance Ca2+-activated potassium (SK) channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2+ levels and membrane potential (Adelman et al., 2012). Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes (Xu et al., 2003). This suggests that the

关 键 词：隧道 CA2+ 

分 类 号：U455.4[建筑科学—桥梁与隧道工程] TQ53[交通运输工程—道路与铁道工程]