安灭菌治疗小儿急性化脓性扁桃体炎的临床疗效观察  

Clinical Curative Effect of Amoxicillin Clavulanate Potassium in the Treatment of Children with Suppurative Tonsillitis

作　　者：朱秀云[1] 陈秀敏[1] Zhu Xiuyun,Chen Xiumin(Department of Pediatrics, XuanWu Hospital of Capital Medical University, Beijing 100053, Chin)

机构地区：[1]首都医科大学宣武医院儿科,北京市100053

出　　处：《中国病案》2018年第5期94-96,共3页Chinese Medical Record

摘　　要：目的探讨静脉注射安灭菌治疗小儿急性化脓性扁桃体炎的疗效和使用该药物的安全性。方法将2015年1月-2017年1月某院门急诊治疗的急性化脓性扁桃体炎患儿118例随机分为对照组58例和实验组60例。对照组给予头孢曲松钠静脉注射治疗,剂量为15mg^20 mg/(kg.d),1次/d;实验组给予安灭菌静脉注射治疗,60mg/(kg.d),分2次静脉注射。两组均连续治疗5天~7天。使用卡方检验比较两组临床疗效;t检验比较两组临床症状和体征消退时间,P<0.05,差异有统计学意义。结果治疗后,实验组总有效率为96.7%,高于对照组的84.5%,试验组患儿体温恢复正常时间、脓点和咽喉及扁桃体充血消退时间均低于对照组,差异有统计学意义,P<0.05。比较两组患儿血白细胞恢复正常时间及不良反应发生率,差异无统计学意义,P>0.05。结论静脉注射安灭菌治疗小儿急性化脓性扁桃体炎疗效良好,无明显不良反应,值得临床推广。Objective To analyze the clinical efficacy and safety of amoxicillin clavulanate potassium in the treatment of children with acute suppurative tonsillitis. Methods Totally 118 children with acute suppurative tonsillitis were randomly divided into the control group（58 cases） and the experimental group（60 cases）. The control group was with intravenous infusion of ceftriaxone sodium for treatment, 15-20 mg/（kg.d）, once/d, and the experimental group was with intravenous infusion of amoxicillin clavulanate potassium, 60 mg/（kg.d）,twice/d. Two groups were treated for 5 to 7 days. The clinical efficacy of the two groups was compared by chi-square test. T test compared two groups of clinical symptoms and signs of regression time, P〈0.05 the differences were statistically significant. Results After the treatment, the total efficiency rate in the experimental group（96.7%） was significantly higher than that in the control group（84.5%）（P〈0.05）. The times of temperature returning to normal, the disappearance times of purulent and pharyngeal hyperaemia fading in the experimental group were all shorter than the control group（P〈0.05）. There was no significant difference in the effects on the normal time of white blood cells between the two groups, and no significant adverse reactions showed in both groups. Conclusions Amoxicillin clavulanate potassium exhibits obvious therapeutic effect on pediatric acute suppurative tonsillitis,which can effectively improve the clinical symptoms without obvious adverse reactions, and it is worthy of further clinical promotion and application.

关 键 词：安灭菌 头孢曲松钠 小儿急性化脓性扁桃体炎 疗效 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]